Integrative Bioinformatics Links HNF1B with Clear Cell Carcinoma and Tumor-Associated Thrombosis

@inproceedings{Cuff2013IntegrativeBL,
  title={Integrative Bioinformatics Links HNF1B with Clear Cell Carcinoma and Tumor-Associated Thrombosis},
  author={Justin Cuff and Keyan Salari and Nicole A Clarke and Ghada E. Esheba and Andrew D. Forster and Stephanie M. Huang and Robert B. West and John P. T. Higgins and Teri A. Longacre and Jonathan R. Pollack},
  booktitle={PloS one},
  year={2013}
}
Clear cell carcinoma (CCC) is a histologically distinct carcinoma subtype that arises in several organ systems and is marked by cytoplasmic clearing, attributed to abundant intracellular glycogen. Previously, transcription factor hepatocyte nuclear factor 1-beta (HNF1B) was identified as a biomarker of ovarian CCC. Here, we set out to explore more broadly the relation between HNF1B and carcinomas with clear cell histology. HNF1B expression, evaluated by immunohistochemistry, was significantly… CONTINUE READING
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