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Hepatocyte Nuclear Factor 1-alpha

Known as: Hepatocyte Nuclear Factor 1-alpha [Chemical/Ingredient], Liver Specific Transcription Factor LF B1, Liver-Specific Transcription Factor LF-B1 
Hepatocyte nuclear factor 1-alpha (631 aa, ~67 kDa) is encoded by the human HNF1A gene. This protein plays a role in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

23 relations
ALK PathwayCell NucleusDNA-Binding ProteinsGenes, Regulator

Papers overview

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2017
2017
POU 2 F 1 promotes growth and metastasis of hepatocellular carcinoma through the FAT 1 signaling pathway
Increasing evidence suggests that POU domain class 2 transcription factor 1 (POU2F1) participates in carcinogenesis and cancer… 
2017
2017
Genotype-based personalized correction of glycemic control in patients with MODY due to mutations in GCK, HNF1A AND HNF4A genes
Aims . To demonstrate the principles of personalized treatment of diabetes for example the most common MODY subtypes (1-3… 
Review
2013
Review
2013
Gastric perforation secondary to regression of lung adenocarcinoma after gefitinib treatment.
Case Report In July 2011, an 80-year-old man presented to our hospital with gradual-onset malaise, poor appetite, and weakness of… 
2011
2011
Restoration of miR-517 a expression induces cell apoptosis in bladder cancer cell lines
the aim of this study was to find novel tumor suppressor micrornAs through screening genes epigenetically silenced by methylation… 
2010
2010
Thyroid transcription factor 1 influences the early phase of compensatory lung growth in adult mice
2005
2005
[Molecular diagnosis on indication of maturity onset diabetes of the young; results from 184 patients].
OBJECTIVE To describe the results of mutation analysis of the genes involved in maturity onset diabetes of the young (MODY) types… 
Review
2005
Review
2005
[MODY types of diabetes mellitus].
Maturity-onset diabetes of the young (MODY) is a monogenic subtype of diabetes mellitus characterized by a young onset of type 2… 
2004
2004
Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and…
1999
1999
The Role of HNF-1 a in Controlling Hepatic Catalase Activity
Mice deficient in hepatocyte nuclear factor 1a (HNF-1a) develop Laron dwarfism and non-insulin-dependent diabetes mellitus (Lee… 
1993
1993
Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.
The POU family of proteins binds specifically to octamer DNA motifs present in the promoters of several genes and regulates their…