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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
TLDR
An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.
Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.
TLDR
Data demonstrate that the chemical composition and functional activity of surfactant is altered in ARDS, suggesting that these abnormalities occur early in the disease process.
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction
TLDR
A triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline transactivator (rtTA)/tetracyCline-responsive element (tet-O)-driven transgenes, that will be useful for studying genes in which temporal control of expression is necessary for the discovery of the full spectrum of functions.
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
TLDR
It is demonstrated that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner and Interestingly, genetic evidence indicates that these functions require different gene dosages of Foxa 1 and FoxA2.
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.
TLDR
It is shown that SAM-pointed domain-containing Ets-like factor (SPDEF) controls a transcriptional program critical for pulmonary goblet cell differentiation in mice and plays a critical role in regulating a transcriptionAL network mediating the gobleT cell differentiation and mucus hyperproduction associated with chronic pulmonary disorders.
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
TLDR
Transgenic mice that express murine K-Ras4b(G12D) under the control of doxycycline in type II pneumocytes show that the appearance and regression of these pulmonary tumors can be readily monitored in anesthetized transgenic animals by magnetic resonance imaging.
Early restriction of peripheral and proximal cell lineages during formation of the lung
TLDR
Early restriction of endodermal progenitor cells forming peripheral as compared with proximal airways is demonstrated, distinct cell lineages in conducting airways are identified, and a system for conditional gene addition or deletion is useful for the study of lung morphogenesis and gene function in vivo.
A mutation in the surfactant protein C gene associated with familial interstitial lung disease.
TLDR
The lungs in patients with chronic pneumonitis of infancy are characterized by interstitial thickening with mesenchymal cells, rather than by an inflammatory infiltrate, and an alveolar infiltrate.
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