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The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution. Since the previous review in 1991, sequencesExpand
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Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases, have been identified in the human, mouse and rat genomes and in other mammalian species. This review providesExpand
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Profiles of strontium and barium in Mercenaria mercenaria and Spisula solidissima shells
Abstract Cross sections of two Mercenaria mercenaria shells, one modern and one Pleistocene, and one modern Spisula solidissima shell were analyzed for trace metals using laser ablation-inductivelyExpand
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Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with important roles in metabolic adaptation, normal physiology and dioxin toxicology. Metabolic adaptation is based onExpand
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Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the bHLH/PAS (basic Helix-Loop-Helix/Per-Arnt-Sim) family of chemosensors and developmental regulators. ItExpand
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The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes.
The impact of gender, use of oral contraceptive steroids (OCS), coffee consumption and of smoking on the metabolism of sparteine, caffeine, and paracetamol was studied in 194 randomly selectedExpand
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Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor.
Coordinate regulation of Phase I and II drug-metabolizing enzymes and conjugate transporters by nuclear receptors suggests that these proteins evolved to an integrated biotransformation system. TwoExpand
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Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in
Polymorphisms of drug metabolizing enzymes are frequently associated with diseases and side effects of drugs. Recently, a TATA box mutation of UGT1A1 (UGT1A1*28), a common genotype leading toExpand
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Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels.
  • K. Bock
  • Biology, Medicine
  • Biochemical pharmacology
  • 15 September 2010
Ten out of 19 UDP-glucuronosyltransferases (UGTs) are substantially expressed in adult human liver (>1% of total UGTs); 5 UGT1 isoforms (UGT1A1, 1A3, 1A4, 1A6 and 1A9) and 5 UGT2 family membersExpand
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Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects.
  • K. Bock
  • Biology, Medicine
  • Biochemical pharmacology
  • 1 September 2003
UDP-glucuronosyltransferases (UGTs) represent major phase II drug metabolizing enzymes. They are part of a rapidly growing, sequence similarly based superfamily of UDP-glycosyltransferases, includingExpand
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