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HHIP protein, human

Known as: HHIP, HIP, hedgehog interacting protein, human 
Hedgehog-interacting protein (700 aa, ~79 kDa) is encoded by the human HHIP gene. This protein plays a role in the regulation of hedgehog signaling… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

Carrier ProteinsMembrane Glycoproteins
EGF-Like DomainHHIP geneHedgehog Signaling PathwayMetal Ion Binding

Papers overview

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2019
2019
Le rôle de la protéine interagissant avec hedgehog (Hhip) dans la formation rénale modulée par le diabète maternel et dans la néphropathie diabétique
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2017
2017
Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis
Tumor growth is governed by the coordinated action of various types of cells that are present in the tumor environment… 
2016
2016
Endothelial microparticles carrying hedgehog-interacting protein induce continuous endothelial damage in the pathogenesis of acute graft-versus-host disease.
Accumulating evidence suggests that endothelial microparticles (EMPs), a marker of endothelial damage, are elevated in acute… 
2015
2015
Secreted HHIP 1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function
Hedgehog (HH) signaling is indispensable for embryogenesis (McMahon et al., 2003). Secreted HH ligands act over long distances to… 
Highly Cited
2015
Highly Cited
2015
Canonical wnt signaling is required for commissural axon guidance
Morphogens have been identified as guidance cues for postcrossing commissural axons in the spinal cord. Shh has a dual effect on… 
2014
2014
Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands.
2010
2010
Gli2 influences proliferation in the developing lung through regulation of cyclin expression.
The sonic hedgehog (Shh) signaling pathway is crucial for normal lung development. In the lung, epithelial-produced Shh signals… 
2006
2006
Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.
2004
2004
Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Previously, it has been shown that… 
2002
2002
Expression of a sonic hedgehog signal transducer, hedgehog‐interacting protein, by human basal cell carcinoma
Summary Background  Aberrant activation of the hedgehog pathway has been identified in various human tumours, including familial… 
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