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Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages
- S. Gillen, T. Schuster, C. Meyer zum Büschenfelde, H. Friess, J. Kleeff
- MedicinePLoS medicine
- 1 April 2010
Jörg Kleef and colleagues systematically reviewed studies on neoadjuvant therapy and tumor response, toxicity, resection, and survival percentages in pancreatic cancer and suggest that patients with…
Most Pancreatic Cancer Resections are R1 Resections
This study highlights the importance of pathological reporting and suggests that tumor growth patterns and thorough examination but not surgical technique determine R1 resection rates in PDAC.
Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases
Pancreatic leak remains a common complication after distal pancreatectomy, and this series suggests that stapler closure of the pancreatic remnant is associated with a significantly higher fistula rate.
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
- M. Erkan, Simone Hausmann, H. Friess
- Medicine, BiologyNature Reviews Gastroenterology &Hepatology
- 1 August 2012
Targeting the tumour stroma, in combination with chemotherapy, is a promising new option for the treatment of PDAC.
Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial
StellaTUM: current consensus and discussion on pancreatic stellate cell research
Members of the Pancreatic Star Alliance discuss and consolidate current knowledge to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research.
Pancreatic cancer microenvironment
Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells to improve the outcome of this deadly disease.
Etiology‐dependent molecular mechanisms in human hepatocarcinogenesis
The findings suggest that MDM4 and EEF1A2 act as etiology‐independent oncogenes in a significant percentage of HCCs, suggesting that tumors of this etiology develop by way of a distinct MYC‐independent pathomechanism.
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.
The current understanding of the salient pathophysiological, molecular, translational and clinical aspects of this disease are summarized and an outline of potential future directions for pancreatic cancer research and patient management is presented.