Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

@article{Ochi2006HhipRZ,
  title={Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.},
  author={Haruki Ochi and Bret J Pearson and Pao-Tien Chuang and Matthias Hammerschmidt and Monte Westerfield},
  journal={Developmental biology},
  year={2006},
  volume={297 1},
  pages={127-40}
}
Sharp borders between cells with different developmental fates are important for patterning of invertebrates, but are not well understood in vertebrates. Zebrafish slow muscle cells develop from adaxial cells, a one-cell-diameter-thick pseudo-epithelium immediately adjacent to the notochord. Hedgehog (Hh) signals from notochord specify adaxial cells to form slow muscle cells. Cells next to adaxial cells form fast muscle. This suggests that Hh signaling is locally regulated to produce a sharp… CONTINUE READING
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The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish Brachydanio rerio, 4th ed

  • M. Westerfield
  • 2000
Highly Influential
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