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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
TLDR
Analysis of an Ihh null mutant and results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes.
Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva.
TLDR
Analysis of the behavioral defects suggests that these genes participate in the diverse locomotion patterns observed, such as touch response, rhythmic tail movements, equilibrium control, or that they simply confer general motility to the animal.
The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.
TLDR
It is demonstrated that the swirl phenotype is caused by mutations in the zebrafish bmp2 gene (zbmp2), and analysis shows that swirl/BMP2, unlike mouse Bmp2 but like mouse BMP4, is required for early dorsoventral patterning of theZebrafish embryo.
The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension.
TLDR
Experimental and genetic evidence is provided that glypican Knypek acts during vertebrate gastrulation as a positive modulator of noncanonical Wnt signaling to establish polarized cell behaviors underlying convergent extension movements.
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.
TLDR
The similar and overlapping phenotypes of mutants of the 6 genes identified suggest that they function in a common pathway, which begins in oogenesis, but also depends on factors provided after the onset of zygotic transcription, presumably during blastula stages.
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
TLDR
Results indicate that PKA acts in target cells as a common negative regulator of Hedgehog signaling, and is suppressed in embryos injected with RNA encoding a constitutively active catalytic subunit of PKA (PKA*).
parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube.
TLDR
The results thus highlight novel and crucial in vivo roles for Ncad in the control of cell convergence, maintenance of neuronal positioning and dorsal cell proliferation during vertebrate neural tube development.
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
TLDR
It is estimated that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of the screen, and the limits and the potentials of a genetic saturation screen in the zebrafish.
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
TLDR
The high rate of induction and recovery of point mutations, in addition to an efficient aquarium system to house large numbers of mutagenized lines, means that it is now possible to perform saturation mutagenesis screens in a vertebrate, similar to those done in invertebrates.
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