Ficusin

Known as: Psoralene, Psoralen, Ficusin [Chemical/Ingredient] 
A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long… (More)

Topic mentions per year

Topic mentions per year

1958-2017
05019582017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Because RNA polymerase is a powerful motor, transmission of transcription-generated forces might directly alter DNA structure… (More)
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Highly Cited
2008
Highly Cited
2008
Embryonic stem cells need to maintain genomic integrity so that they can retain the ability to differentiate into multiple cell… (More)
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Highly Cited
2004
Highly Cited
2004
A prerequisite for cellular immortalization in human cells is the elongation of telomeres through the upregulation of telomerase… (More)
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Highly Cited
2002
Highly Cited
2002
We investigated the mechanism of RNA interference (RNAi) in human cells. Here we demonstrate that the status of the 5' hydroxyl… (More)
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Highly Cited
2001
Highly Cited
2001
The innate immune response to intraportally infused adenoviral vector was evaluated in rhesus monkeys. A first-generation… (More)
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Highly Cited
1999
Highly Cited
1999
Mammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric repeat-binding factors TRF1 and TRF2… (More)
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Highly Cited
1999
Highly Cited
1999
Replication-deficient adenoviruses are known to induce acute injury and inflammation of infected tissues, thus limiting their use… (More)
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Highly Cited
1997
Highly Cited
1997
Generalized transcriptional repression of large chromosomal regions in Saccharomyces cerevisiae occurs at the silent mating loci… (More)
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Highly Cited
1997
Highly Cited
1997
We demonstrate that in Saccharomyces cerevisiae, the tandem array of ribosomal RNA genes (RDN1) is a target for integration of… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for… (More)
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