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The optics of human skin.
An integrated review of the transfer of optical radiation into human skin is presented, aimed at developing useful models for photomedicine. The component chromophores of epidermis and stratumExpand
The shape and magnitude of the action spectra are grossly consistent with a mechanism in which DNA is the primary chromophore initiating the response pathways for wavelengths less than 313 nm, which is of practical significance in predicting skin response to sources of ultraviolet radiation. Expand
Photosynthesis of previtamin D3 in human skin and the physiologic consequences.
These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D3 from the skin into the circulation. Expand
Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.
Abstract Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing ofExpand
Microvasculature Can Be Selectively Damaged Using Dye Lasers: A Basic Theory and Experimental Evidence in Human Skin
An approximate, predictive model and data are proposed for the purpose of selecting a laser that maximized damage to cutaneous blood vessels and minimizes damage to the surrounding connective tissue and the overlying epidermis, and highly specific laser‐induced damage to blood vessels is demonstrated both clinically and histologically. Expand
Optical Properties of Human Skin
Despite the many years since optical spectra from human skin were first obtained, only recently have quantitative models of cutaneous optics been applied. This chapter aims to present the optics ofExpand
Oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial.
Once a remission was induced, there was no difference in its maintenance when patients were treated once a week, once every other week, or once every third week, and each of these schedules was superior to no maintenance treatment. Expand
Action spectrum for phototherapy of psoriasis.
Using a monochromator the action spectrum for ultraviolet phototherapy of psoriasis was determined for radiation between 254 and 313 nm and compared to theaction spectrum for erythema of uninvolved adjacent skin, suggesting that monochromaatic radiation may have advantages over broadband sources. Expand
Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects.
Monitoring changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyv vitamin D (1,25-(OH)2-D), over a three-week period in normal subjects and vitamin-D-deficient patients found that exposure to . Expand
Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis.
New patients with known histories of ionizing-radiation exposure or of skin tumors should be given 8-methyoxypsoralen photochemotherapy only if they understand the risks and have disabling psoriasis untreatable by other means. Expand