Share This Author
The Spliceosome: Design Principles of a Dynamic RNP Machine
Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi
Spliceosome structure and function.
The extensive interplay of RNA and proteins in aligning the pre-mRNA's reactive groups, and the presence of both RNA and protein at the core of the splicing machinery, suggest that the spliceosome is an RNP enzyme, but elucidation of the precise nature of its active site awaits the generation of a high-resolution structure of its RNP core.
The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
Identification of Novel Argonaute-Associated Proteins
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
An essential cellular factor for nuclear mRNA export called Mex67p which has homologous proteins in human and Caenorhabditis elegans was identified through its genetic interaction with nucleoporin Nup85p, and is likely to participate directly in the export of mRNA from the nucleus to the cytoplasm.
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.
Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs
Spliceosomal UsnRNP biogenesis, structure and function.