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Molecular basis of sun-induced premature skin ageing and retinoid antagonism
TLDR
It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing). Expand
Pathophysiology of premature skin aging induced by ultraviolet light.
TLDR
Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging. Expand
Mechanisms of photoaging and chronological skin aging.
TLDR
This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways. Expand
Matrix-degrading metalloproteinases in photoaging.
TLDR
Current understanding of the role of MMPs in the photoaging process is summarized and new data are presented that describe the expression and regulation byUV irradiation of all members of the MMP family in human skin in vivo and quantify the relative contributions of epidermis and dermis to the expression of UV irradiation-induced M MPs. Expand
Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways
TLDR
The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders. Expand
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
TLDR
A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci. Expand
Molecular mechanisms of retinoid actions in skin
TLDR
This article will review recent findings in retinoid physiology and pharmacology and attempt to synthesize their meaning to provide a view into the mechanisms whereby retinoids participate in regulation of skin function. Expand
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
TLDR
This genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny, one of these regions (16q) overlaps with a recently-identified susceptibility loci for Crohn's disease. Expand
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
TLDR
Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis. Expand
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
TLDR
A genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany suggests that TRAF3IP2 represents a shared susceptibility for PsV and PsA. Expand
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