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Molecular basis of sun-induced premature skin ageing and retinoid antagonism
It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).
Pathophysiology of premature skin aging induced by ultraviolet light.
- G. Fisher, Z. Wang, S. Datta, J. Varani, S. Kang, J. Voorhees
- Medicine, BiologyThe New England journal of medicine
- 13 November 1997
Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging.
Matrix-degrading metalloproteinases in photoaging.
- T. Quan, Z. Qin, W. Xia, Y. Shao, J. Voorhees, G. Fisher
- BiologyThe journal of investigative dermatology…
- 1 August 2009
Current understanding of the role of MMPs in the photoaging process is summarized and new data are presented that describe the expression and regulation byUV irradiation of all members of the MMP family in human skin in vivo and quantify the relative contributions of epidermis and dermis to the expression of UV irradiation-induced M MPs.
Mechanisms of photoaging and chronological skin aging.
This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways
The results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 × 10−8) and suggest priority targets for study in other auto-immune disorders.
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
This genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny, one of these regions (16q) overlaps with a recently-identified susceptibility loci for Crohn's disease.
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
Molecular mechanisms of retinoid actions in skin
This article will review recent findings in retinoid physiology and pharmacology and attempt to synthesize their meaning to provide a view into the mechanisms whereby retinoids participate in regulation of skin function.
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
Results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.
Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.
It is proposed that this self perpetuating cycle of MMP-1-catalyzed collagen fragmentation and oxidative stress promotes human skin aging and the current understanding of the oxidative theory of aging is extended to include extracellular matrix and the critical role that connective tissue microenvironment plays in the biology of aging.