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Dendritic cells and the control of immunity
Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis and the realization that these cells are a powerful tool for manipulating the immune system is realized.
The dendritic cell system and its role in immunogenicity.
  • R. Steinman
  • Biology, Medicine
    Annual review of immunology
  • 1991
Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
The methodology for inducing dendritic cell growth that was recently described for mouse blood now has been modified to MHC class II- negative precursors in marrow, and this feature should prove useful for future molecular and clinical studies of this otherwise trace cell type.
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
This work targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies and found that this difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
Proliferating dendritic cell progenitors in human blood
Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Tolerogenic dendritic cells.
It is suggested that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells primarily at the immature stage of their differentiation and DC-SIGN, a C-type lectin, may be considered as a new target for designing therapies that block dengue infection.
Taking dendritic cells into medicine
Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral
DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.