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Fenretinide

Known as: N-(4-Hydroxyphenyl)All-Trans Retinamide, 4-hydroxyphenylretinamide, N-(4-Hydroxyphenyl)-trans-Retinamide 
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide… 
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (3)

4-oxofenretinide5-hydroxyphenylbutanoateretinamideMCN-R-1967
Angiogenesis InhibitionApoptosisChemopreventionIn Blood

Broader (3)

Anticarcinogenic AgentsAntineoplastic AgentsRetinoids

Papers overview

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Highly Cited
2005
Highly Cited
2005
Endogenous Fluorescence Spectroscopy of Cell Suspensions for Chemopreventive Drug Monitoring¶
Abstract Cancer chemopreventive agents such as N-4-(hydroxyphenyl)retinamide (4HPR) are thought to prevent cancers by suppressing… 
Highly Cited
2005
Highly Cited
2005
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis
Pancreatic cancer is exceptionally aggressive with no long-term effective therapy. Current interventional approaches, including… 
Review
1996
Review
1996
Bioactivities of N‐(4‐hydroxyphenyl) retinamide and retinoyl β‐glucuronide
N‐(4‐Hydroxyphenyl) retinamide (4HPR) and retinoyl beta‐glucuronide (RAG) are two derivatives of all‐trans retinoic acid (RA… 
Highly Cited
1994
Highly Cited
1994
N-(4-hydroxyphenyl)retinamide: a potent inducer of apoptosis in human neuroblastoma cells.
Highly Cited
1989
Highly Cited
1989
Plasma retinol level reduction by the synthetic retinoid fenretinide: a one year follow-up study of breast cancer patients.
Fenretinide (HPR) is a synthetic retinoid which has been shown to cause a reduction in the incidence of carcinogen-induced… 
Review
1989
Review
1989
Chemoprevention of experimental carcinogenesis in animals.
Highly Cited
1986
Highly Cited
1986
Abnormal retinal function associated with fenretinide, a synthetic retinoid.
Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod… 
Highly Cited
1985
Highly Cited
1985
Effect of 4-hydroxyphenylretinamide and retinoic acid on proliferation and cell cycle of cultured human breast cancer cells.
The synthetic retinoid 4-hydroxyphenylretinamide (HPR) showed antiproliferative effect on cultured human breast cancer cells… 
Highly Cited
1982
Highly Cited
1982
Enhanced inhibition of mammary carcinogenesis by combined treatment with N-(4-hydroxyphenyl)retinamide and ovariectomy.
Bilateral ovariectomy and dietary administration of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are both effective… 
Highly Cited
1982
Highly Cited
1982
Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse.
A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid amides (retinamides) as inhibitors… 
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