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Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles in the developing nervous… Expand Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified… Expand The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and RXRs) which are ligand-activated… Expand Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive… Expand The key role of vitamin A in embryonal development is reviewed. Special emphasis is given to the physiological action of… Expand lntroduction Michael B. Sporn and Anita B. Roberts The Synthetic Chemistry of Retinoids Marcia I. Dawson and Peter D. Hobbs… Expand The nuclear hormone receptors called PPARs (peroxisome proliferator-activated receptors alpha, beta, and gamma) regulate the… Expand All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor… Expand Ro 10-9359 is a retinoic acid derivative, selected for study because of a better tolerance than retinoic acid, shown in animal… Expand An approach to chemoprevention of common forms of epithelial cancer, during the period of preneoplasia, is described. Vitamin A… Expand