Isotretinoin

Known as: Neovitamin a acid, topical isotretinoin, Isotretinoina 
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal antibody against the tumor-associated… (More)
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Highly Cited
2007
Highly Cited
2007
The purpose of this study was to construct isotretinoin-loaded SLN (IT-SLN) formulation with skin targeting for topical delivery… (More)
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Highly Cited
2003
Highly Cited
2003
Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Promising data have suggested that retinoid chemoprevention may help to control second primary tumors (SPTs… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in… (More)
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Review
1997
Review
1997
Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Retinoids are effective in the treatment and prevention of certain human cancers. Most of their actions are thought to… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND High-dose isotretinoin therapy has been determined to be an effective treatment for leukoplakia. However, a high rate… (More)
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Highly Cited
1990
Highly Cited
1990
BACKGROUND Patients with head-and-neck cancers who are free of disease after local therapy remain at high risk for both recurrent… (More)
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Highly Cited
1988
Highly Cited
1988
To confirm reports that skin cancer can be prevented with retinoids, we conducted a three-year controlled prospective study of… (More)
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