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Isotretinoin

Known as: Neovitamin a acid, topical isotretinoin, Isotretinoina 
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs… 
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (7)

AccureAccutane embryopathyIsotrexinOratane
AccutaneAcne VulgarisDrug AllergyImmunoregulation

Broader (3)

Dermatologic AgentsRetinoateTeratogens

Papers overview

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1991
1991
Cost effectiveness of isotretinoin
OBJECTIVE To determine the relative cost effectiveness of long term rotational antibiotics and isotretinoin for moderate/severe… 
1986
1986
Isotretinoin-induced craniofacial malformations in humans and hamsters.
: Oral administration of 40-80 mg/d of isotretinoin (13-cis-retinoic acid, Ro 4-3780, Accutane) during the first month of human… 
1985
1985
Identification of the cellular retinoic acid binding protein (cRABP) within the embryonic mouse (CD-1) limb bud.
Retinoic acid, a physiologically active metabolite of vitamin A, is known animal teratogen. Among other malformations, limb… 
1984
1984
Treatment of basal cell carcinoma with 13-cis-retinoic acid.
Patients with basal cell carcinoma were treated locally with 13-cis-retinoic acid. Disappearance of the tumors was observed in… 
1983
1983
Induction of ornithine decarboxylase activity and DNA synthesis in hairless mouse epidermis by retinoids.
The ability of all-trans-retinoic acid (RA) and other retinoid derivatives to enhance DNA synthesis and to induce ornithine… 
1982
1982
Augmentation of collagen arthritis by synthetic analogues of retinoic acid.
We evaluated the effect of administering orally two synthetic analogues of retinoic acid, 13-cis-retinoic acid and all-trans-N-(4… 
1981
1981
Effect of inhibitors of tumorigenesis on the formation of O6-methylguanine in the colon of 1,2-dimethylhydrazine-treated rats.
The level of O6-methylguanine (O6MeGua) in the colonic DNA of rats treated with 1,2-dimethylhydrazine was determined. The effect… 
Highly Cited
1980
Highly Cited
1980
Comparative effects of all-trans and 13-cis retinoic acid administration on serum and liver lipids in rats.
The effects of all-trans and 13-cis retinoic acid upon serum and liver lipids were investigated in Sprague-Dawley rats. Groups of… 
1979
1979
Fluorinated retinoic acids and their analogues. 1. Synthesis and Biological activity of (4-methoxy-2,3,6-trimethylphenyl)nonatetraenoic acid analogues.
(4-Methoyx-2,3,6-trimethylphenyl)nonatetraenoic acids, esters, and amides (analogues of retinoic acid) bearing a fluorine atom(s… 
Highly Cited
1977
Highly Cited
1977
Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.
An objective system for histopathological and statistical evaluation of rat bladder lesions induced by the carcinogen, N-methyl-N…