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Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.
Methylation of the RAR-beta2 gene may be an initial step in breast carcinogenesis; treatment of cancer patients with demethylating agents followed by retinoic acid may offer a new therapeutic modality. Expand
Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients.
For patients with lymph node-negative breast cancer, uPA and PAI-1 measurements in primary tumors may be especially useful for designing individualized treatment strategies. Expand
Determination of neopterin in serum and urine.
It is found that in patients with gynecological tumors, the latter values (measured by HPLC) discriminated slightly better between patients with favorable and unfavorable prognoses, and the RIA should be used only for measuring neopterin in serum. Expand
Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer.
A crucial role of RAR-beta in the carcinogenesis of breast cancer is indicated, and Sequencing the DNA extracted from paraffin-embedded tumor tissue of the corresponding breast cancer specimens was not able to detect any mutation in the retinoic acid-responsive element. Expand
Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer.
In ovarian cancer, high ascitic-fluid IL-12 levels, which may indicate a local Th1-generated immune response, are associated with disease progression. Expand
Human peritoneal mesothelial cells are more potent than ovarian cancer cells in producing tumor marker CA-125.
Investigation of the extent to which human peritoneal mesothelial cells are able to participate in the release of tumor marker CA-125 in ovarian cancer and other conditions associated with an involvement of the peritoneum found it to be about five times higher in HPMCs as compared with the investigated ovarian cancer cell lines. Expand
Clinical significance of serum and ascitic p53 autoantibodies in epithelial ovarian carcinoma
This retrospective study was performed to evaluate the prognostic significance of preoperative serum and ascitic anti‐p53 antibodies in advanced ovarian carcinoma. Expand
Interferon-gamma expression is an independent prognostic factor in ovarian cancer.
Elevated interferon-gamma expression correlates with improved clinical outcome in patients with ovarian cancer, and application of multivariate Cox regression analysis showed interferons-gammas expression to be an independent prognostic factor for progression-free and overall survival. Expand
Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer
Similar to p73, the tumor suppressor gene p53 is subject to alternative splicing. Besides p53ΔE6 and p53β, we identified p53ζ, p53δ and p53ɛ, arising from alternative splicing of exon 6 and intron 9,Expand
Favorable prognostic value of SOCS2 and IGF-I in breast cancer
The results suggest that high expression of the STAT5 target genes SOCS2 and IGF-I is a feature of differentiated and less malignant tumors. Expand