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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans. Expand
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.
The data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer, and exerts mixed estrogen agonist/antagonist activities in some mammary cancer cell lines, but in the presence of E2, resver atrol functions as an antiestrogen. Expand
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
The findings suggest that clinical trials to further assess chemopreventive and adjuvant therapeutic applications of pomegranate in human breast cancer may be warranted. Expand
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the most active. Expand
Human, Rat, and Mouse Metabolism of Resveratrol
AbstractPurpose. Resveratrol, a phenolic phytoalexin occurring in grapes, wine, peanuts, and cranberries, has been reported to have anticarcinogenic, antioxidative, phytoestrogenic, andExpand
Evaluation of the antioxidant potential of natural products.
Of these substances, the hydroxystilbenes piceatannol and transresveratrol have thus far been shown to inhibit carcinogen-induced preneoplastic lesion formation in the mouse mammary gland organ culture model. Expand
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Pterostilbene was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Expand
Expression of Vitamin D Receptor and 25-Hydroxyvitamin D3-1α-Hydroxylase in Normal and Malignant Human Colon
Results show that 1α-hydroxylase is present at equal high levels in normal colonic epithelium as in ACFs, polyps, and colorectal cancer irrespective of tumor cell differentiation, and suggest that pro-vitamin D is less likely to be useful for coloreCTal cancer chemotherapy. Expand
Cancer Chemoprevention by Natural Products: How Far Have We Come?
Novel technologies, such as nanotechnology, along with a better understanding of cancer stem cells, are certain to continue the advancement of the field of cancer chemoprevention in years to come. Expand
Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems.
The data suggest that structural elements responsible for COX-1 and COx-2 inhibition do not correlate well with those responsible for inhibitingCOX-2 and iNOS gene expression, but elements capable of inhibiting COX/Nos gene expression also contribute to inhibition of TPA-induced ODC activity. Expand