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FYN protein, human

Known as: p59-FYN, Src-Like Kinase, Proto-Oncogene Syn 
Tyrosine-protein kinase Fyn (537 aa, ~61 kDa) is encoded by the human FYN gene. This protein is involved in tyrosine phosphorylation, cytoskeleton… 
National Institutes of Health

Related topics

Related topics

31 relations
Axon GuidanceCell Cycle ControlCell Differentiation processCell Proliferation

Broader (1)

Proto-Oncogene Proteins c-fyn

Papers overview

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Highly Cited
2019
Highly Cited
2019
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Fyn kinase mediates aggregated α-synuclein (αSyn) uptake as well as αSyn-mediated proinflammatory signaling in microglia, leading… 
Highly Cited
2007
Highly Cited
2007
GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.
NF-E2-related factor 2 (Nrf2) regulates expression and coordinated induction of a battery of chemoprotective genes in response to… 
Highly Cited
2004
Highly Cited
2004
Regulation of TRPC6 Channel Activity by Tyrosine Phosphorylation*
Various hormonal stimuli and growth factors activate the mammalian canonical transient receptor potential (TRPC) channel through… 
Highly Cited
2003
Highly Cited
2003
Fyn Tyrosine Kinase Is a Critical Regulator of Disabled-1 during Brain Development
Highly Cited
2003
Highly Cited
2003
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We… 
Highly Cited
2003
Highly Cited
2003
Involvement of BDNF receptor TrkB in spatial memory formation.
The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several… 
Highly Cited
1997
Highly Cited
1997
Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin
The N‐methyl‐D‐aspartate receptor (NMDA‐R) and brain spectrin, a protein that links membrane proteins to the actin cytoskeleton… 
Highly Cited
1997
Highly Cited
1997
Rapid Plasma Membrane Anchoring of Newly Synthesized p59  fyn: Selective Requirement for NH2-Terminal Myristoylation and Palmitoylation at Cysteine-3
The trafficking of Src family proteins after biosynthesis is poorly defined. Here we studied the role of dual fatty acylation… 
Highly Cited
1994
Highly Cited
1994
Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
Two src family kinases, lck and fyn, participate in the activation of T lymphocytes. Both of these protein tyrosine kinases are… 
Highly Cited
1993
Highly Cited
1993
Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
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