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FYN protein, human

Known as: p59-FYN, Src-Like Kinase, Proto-Oncogene Syn 
Tyrosine-protein kinase Fyn (537 aa, ~61 kDa) is encoded by the human FYN gene. This protein is involved in tyrosine phosphorylation, cytoskeleton… 
National Institutes of Health

Related topics

Related topics

31 relations
Axon GuidanceCell Cycle ControlCell Differentiation processCell Proliferation

Broader (1)

Proto-Oncogene Proteins c-fyn

Papers overview

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Highly Cited
2007
Highly Cited
2007
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.
In primary human T cells, anergy induction results in enhanced p59Fyn activity. Because Fyn is the kinase primarily responsible… 
Highly Cited
2007
Highly Cited
2007
Regulation of NaV1.2 Channels by Brain-Derived Neurotrophic Factor, TrkB, and Associated Fyn Kinase
Voltage-gated sodium channels are responsible for action potential initiation and propagation in neurons, and modulation of their… 
2006
2006
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Scaffolding adapter Grb2-associated binder 2 (Gab2) is a key component of FcepsilonRI signaling in mast cells, required for the… 
Highly Cited
2003
Highly Cited
2003
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward.
BACKGROUND The tyrosine kinase Fyn previously has been shown to play a key role in mediating acute tolerance to ethanol. Recently… 
Highly Cited
1998
Highly Cited
1998
CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes
CD44 is the major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan and is implicated in a variety… 
Highly Cited
1997
Highly Cited
1997
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling
The Src family protein tyrosine kinases (PTKs), Lck and Fyn, are coexpressed in T cells and perform crucial functions involved in… 
Highly Cited
1996
Highly Cited
1996
Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells*
Fyn is a Src family protein-tyrosine kinase functionally associated with the T-cell antigen receptor (TcR)/CD3 receptor complex… 
Highly Cited
1996
Highly Cited
1996
CD43-specific Activation of T Cells Induces Association of CD43 to Fyn Kinase*
CD43, the most abundant membrane protein of T lymphocytes, is able to initiate signal transduction pathways that lead to Ca2… 
1996
1996
Molecular cloning and characterization of Byp, a murine receptor‐type tyrosine phosphatase similar to human DEP‐1
Highly Cited
1992
Highly Cited
1992
Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.
Three members of the Src family of tyrosine kinases [pp60c-src (Src), p59fyn (Fyn) and pp62c-yes (Yes)] are ubiquitously… 
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