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Proto-Oncogene Proteins c-fyn

Known as: Proto Oncogene Protein c syn, c-fyn, Proto-Oncogene Proteins, Proto-Oncogene Protein c-syn 
Src-family kinases that associate with T-CELL ANTIGEN RECEPTOR and phosphorylate a wide variety of intracellular signaling molecules.
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (4)

FYN protein, humanProto-Oncogene Protein p59(fyn)Proto-Oncogene Protein p60(fyn)Proto-Oncogene Protein p72(fyn)
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2007
Highly Cited
2007
PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.
Src-specific activity has been reported to be elevated in a high percentage of colon cancer cell lines and tumors, but the… 
Highly Cited
2007
Highly Cited
2007
Conformational control of transmembrane Cl(-) transport.
Preorganization of the isophthalamide cleft in N,N‘-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen… 
Highly Cited
2005
Highly Cited
2005
Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy
Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic… 
Highly Cited
2003
Highly Cited
2003
PTPα regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
We investigated the molecular and cellular actions of receptor protein tyrosine phosphatase (PTP) α in integrin signaling using… 
Highly Cited
1999
Highly Cited
1999
Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase*
We have investigated the interaction between Cbl and the Src-related tyrosine kinase Fyn. Fyn was observed to be constitutively… 
Highly Cited
1999
Highly Cited
1999
Dual Fatty Acylation of p59Fyn Is Required for Association with the T Cell Receptor ζ Chain through Phosphotyrosine–Src Homology Domain-2 Interactions
The first 10 residues within the Src homology domain (SH)–4 domain of the Src family kinase Fyn are required for binding to the… 
Review
1998
Review
1998
Fyn, a Src family tyrosine kinase.
Highly Cited
1997
Highly Cited
1997
Rapid Plasma Membrane Anchoring of Newly Synthesized p59  fyn: Selective Requirement for NH2-Terminal Myristoylation and Palmitoylation at Cysteine-3
The trafficking of Src family proteins after biosynthesis is poorly defined. Here we studied the role of dual fatty acylation… 
Highly Cited
1995
Highly Cited
1995
The F3 Neuronal Glycosylphosphatidylinositol‐Linked Molecule Is Localized to Glycolipid‐Enriched Membrane Subdomains and Interacts with L1 and Fyn Kinase in Cerebellum
Abstract: The F3 molecule is a member of the immunoglobulin superfamily anchored to plasma membranes by a… 
Highly Cited
1992
Highly Cited
1992
An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity.
An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(a)pyrene (BP… 
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