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Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.
  • M. Resh
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 12 August 1999
Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and cellular proteins. This review will highlight the latest advances in our understanding of the enzymology ofExpand
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Trafficking and signaling by fatty-acylated and prenylated proteins
  • M. Resh
  • Biology, Medicine
  • Nature chemical biology
  • 1 November 2006
A wide variety of signaling proteins are modified by covalently linked fatty acids and/or prenyl groups. These hydrophobic moieties, which include myristate, palmitate, farnesyl and geranylgeranyl,Expand
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Palmitoylation of Ligands, Receptors, and Intracellular Signaling Molecules
  • M. Resh
  • Biology, Medicine
  • Science's STKE
  • 31 October 2006
Palmitate, a 16-carbon saturated fatty acid, is attached to more than 100 proteins. Modification of proteins by palmitate has pleiotropic effects on protein function. Palmitoylation can influenceExpand
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Multimerization of Human Immunodeficiency Virus Type 1 Gag Promotes Its Localization to Barges, Raft-Like Membrane Microdomains
ABSTRACT The Gag polyprotein of human immunodeficiency virus type 1 (HIV-1) organizes the assembly of nascent virions at the plasma membrane of infected cells. Here we demonstrate that a populationExpand
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Signaling from Integrins to Fyn to Rho Family GTPases Regulates Morphologic Differentiation of Oligodendrocytes
Differentiation of oligodendrocyte progenitor cells requires activation of the Src family kinase Fyn. The signals that are upstream and downstream of Fyn in oligodendrocytes remain essentiallyExpand
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Myristylation and palmitylation of Src family members: The fats of the matter
  • M. Resh
  • Biology, Medicine
  • Cell
  • 11 February 1994
  • 642
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Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids.
Retroviral Gag proteins are targeted to the plasma membrane, where they play the central role in virion formation. Several studies have suggested that the membrane-binding signal is contained withinExpand
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Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids*
The ability of the Src family kinases Fyn and Lck to participate in signaling through the T cell receptor is critically dependent on their dual fatty acylation with myristate and palmitate. Here weExpand
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Morphological Differentiation of Oligodendrocytes Requires Activation of Fyn Tyrosine Kinase
In the central nervous system, myelination of axons occurs when oligodendrocyte progenitors undergo terminal differentiation and initiate process formation and axonal ensheathment. Although it isExpand
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Differential membrane binding of the human immunodeficiency virus type 1 matrix protein.
The human immunodeficiency virus type 1 matrix protein (p17MA) plays a central role at both the early and late stages of the virus life cycle. During viral assembly, the p17MA domain of Pr55gagExpand
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