• Publications
  • Influence
Structure and regulation of voltage-gated Ca2+ channels.
  • W. Catterall
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 2000
TLDR
The distinct structures and patterns of regulation of these three families of Ca(2+) channels provide a flexible array of Ca('s 2+) entry pathways in response to changes in membrane potential and a range of possibilities for regulation of Ca (2+) entry by second messenger pathways and interacting proteins. Expand
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
TLDR
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) database provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome, and provides an expanded substrate for the biennially published compendium, the Concise Guide topharmacology. Expand
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
TLDR
The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided. Expand
International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
TLDR
The molecular relationships and physiological roles of these sodium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided. Expand
THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL
TLDR
This crystal structure of a voltage-gated Na+ channel from Arcobacter butzleri (NavAb) captured in a closed-pore conformation with four activated voltage sensors provides the template for understanding electrical signalling in excitable cells and the actions of drugs used for pain, epilepsy and cardiac arrhythmia at the atomic level. Expand
Voltage-gated calcium channels.
  • W. Catterall
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 1 August 2011
TLDR
The molecular relationships and physiological functions of these voltage-gated Ca(2+) channel proteins are presented and information on their molecular, genetic, physiological, and pharmacological properties is provided. Expand
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
TLDR
The results indicate that reduced sodium currents in GABAergic inhibitory interneurons in Scn1a+/− heterozygotes may cause the hyperexcitability that leads to epilepsy in patients with SMEI. Expand
Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
TLDR
The results suggest that the Ca2+ influx into the calyx via N- and R-type channels triggers release less effectively than that via P/Q-type because a substantial fraction of the N-and- R- type channels in thecalyx is localized distant from release sites. Expand
Nomenclature of Voltage-Gated Calcium Channels
TLDR
A new nomen-ties of the channel complex, the pharmacological and clature of voltage-gated Ca 2ϩ channels, which electrophysiological diversity of Ca 2 ϩ channels arises is more systematic and mimics the well-defined K ϩ primarily from the existence of multiple forms of ␣ 1 sub-channel nomenclature. Expand
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