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FERMT3 protein, human

Known as: MIG2-Like Protein, Unc-112-Related Protein 2, Kindlin-3 
Fermitin family homolog 3 (667 aa, ~76 kDa) is encoded by the human FERMT3 gene. This protein plays a role in hematopoietic cell adhesion, migration… 
National Institutes of Health

Related topics

Related topics

10 relations
Actin-Binding ProteinCell-Cell Adhesion ProcessFERMT3 geneIntegrin Binding

Broader (2)

Membrane ProteinsNeoplasm Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state
Kindlin-1, -2, and -3 directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their… 
2018
2018
Kindlin‐3 negatively regulates the release of neutrophil extracellular traps
Neutrophils fight infections by generating reactive oxygen species (ROS) and extracellular traps (NETs). However, how neutrophils… 
2015
2015
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D
Directed neutrophil migration in blood vessels and tissues is critical for proper immune function; however, the mechanisms that… 
Highly Cited
2014
Highly Cited
2014
Kindlin‐3 enhances breast cancer progression and metastasis by activating Twist‐mediated angiogenesis
The FERM domain containing protein Kindlin‐3 has been recognized as a major regulator of integrin function in hematopoietic cells… 
2013
2013
The Kindlin 3 Pleckstrin Homology Domain Has an Essential Role in Lymphocyte Function-associated Antigen 1 (LFA-1) Integrin-mediated B Cell Adhesion and Migration
Background: Kindlin 3 is mutated in LAD-III causing widespread infection, but its role in leukocyte function is incompletely… 
2013
2013
A Role of Kindlin-3 in Integrin αMβ2 Outside-In Signaling and the Syk-Vav1-Rac1/Cdc42 Signaling Axis
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling receptors because their… 
Highly Cited
2012
Highly Cited
2012
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.
In inflammation, neutrophils and other leukocytes roll along the microvascular endothelium before arresting and transmigrating… 
2011
2011
Talin-1 and Kindlin-3 Regulate α4β1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation
Chemokine/chemoattractant G protein-coupled receptors trigger an inside–out signaling network that rapidly activates integrins, a… 
Highly Cited
2011
Highly Cited
2011
A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion
Leukocyte adhesion deficiency type III is a recently described condition involving a Glanzmann-type bleeding syndrome and… 
Highly Cited
2009
Highly Cited
2009
Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells
Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell–specific… 
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