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Rapid leukocyte migration by integrin-independent flowing and squeezing
TLDR
It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge. Expand
The Tail of Integrins, Talin, and Kindlins
TLDR
This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-β subunits. Expand
Genetic and cell biological analysis of integrin outside-in signaling.
TLDR
This review discusses recent work that has tremendously broadened the understanding of the complexity of integrin-mediated signaling. Expand
Kindlin-2 controls bidirectional signaling of integrins.
TLDR
It is found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindin-2 is required for talin-induced integrin activation, and it is demonstrated that Kindlins-2 are required for integrin outside-in signaling to enable firm adhesion and spreading. Expand
Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes
TLDR
The chondrodysplasia is characterized by a reduction of the fibrillar collagen network, shortened collagen fibers, and elevated expression of cartilage extracellular matrix genes, suggesting that perlecan protects cartilageextracllular matrix from degradation. Expand
Negative Regulation of Fibroblast Motility by Ena/VASP Proteins
TLDR
Using overexpression, loss-of-function, and inhibitory approaches, it is found that Ena/VASP proteins negatively regulate fibroblast motility. Expand
Kindlin-3 is essential for integrin activation and platelet aggregation
TLDR
Kindlin-3 is identified as a novel and essential element for platelet integrin activation in hemostasis and thrombosis because it can directly bind to regions of β-integrin tails distinct from those of Talin and trigger integrinactivation. Expand
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
TLDR
It is shown that beta cells, in contrast to the exocrine pancreatic cells, do not form a basement membrane, but by using VEGF-A, they attract endothelial cells, which form capillaries with a vascular basement membrane next to the beta cells. Expand
Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling
TLDR
The data indicate that, depending on the external signals, Cyld can negatively regulate different NF-kappaB pathways; inactivation of TRAF2 controls survival and inflammation, while inhibition of Bcl-3 controls proliferation and tumor growth. Expand
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
TLDR
This study assigns specific functions to distinct fibronectin-binding integrins, demonstrating that α5β1integrins accomplish force generation, whereas αv-class Integrins mediate the structural adaptations to forces, which cooperatively enable cells to sense the rigidity of fibronECTin-based microenvironments. Expand
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