Rapid leukocyte migration by integrin-independent flowing and squeezing
It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge.
Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes
The chondrodysplasia is characterized by a reduction of the fibrillar collagen network, shortened collagen fibers, and elevated expression of cartilage extracellular matrix genes, suggesting that perlecan protects cartilageextracllular matrix from degradation.
The Tail of Integrins, Talin, and Kindlins
This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-β subunits.
Genetic and cell biological analysis of integrin outside-in signaling.
This review discusses recent work that has tremendously broadened the understanding of the complexity of integrin-mediated signaling.
Negative Regulation of Fibroblast Motility by Ena/VASP Proteins
Kindlin-2 controls bidirectional signaling of integrins.
It is found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindin-2 is required for talin-induced integrin activation, and it is demonstrated that Kindlins-2 are required for integrin outside-in signaling to enable firm adhesion and spreading.
Kindlin-3 is essential for integrin activation and platelet aggregation
- M. Moser, B. Nieswandt, S. Ussar, M. Požgajová, R. Fässler
- Biology, MedicineNature Network Boston
- 1 March 2008
Kindlin-3 is identified as a novel and essential element for platelet integrin activation in hemostasis and thrombosis because it can directly bind to regions of β-integrin tails distinct from those of Talin and trigger integrinactivation.
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
This study assigns specific functions to distinct fibronectin-binding integrins, demonstrating that α5β1integrins accomplish force generation, whereas αv-class Integrins mediate the structural adaptations to forces, which cooperatively enable cells to sense the rigidity of fibronECTin-based microenvironments.
Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling