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The insider's guide to leukocyte integrin signalling and function
This Review focuses on the integrin lymphocyte function-associated antigen 1 (LFA1), which is expressed by T cells, and explores how disparate signalling pathways synergize to regulate LFA1 activity. Expand
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.
Newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution are indicated. Expand
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
A network of paracrine signals between carcinoma, myeloid, and endothelial cells that drives both processes in breast cancer is uncovered, and a mechanism linking chemoresistance and metastasis, with opportunities for intervention is provided. Expand
Divalent cation regulation of the function of the leukocyte integrin LFA-1
The integrin lymphocyte function-associated antigen-1 (LFA-1) expressed on T cells serves as a useful model for analysis of leukocyte integrin functional activity. We have assessed the role ofExpand
Reversal of the TCR Stop Signal by CTLA-4
It is shown that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells, which suggests a fundamentally different model of reverse stop signaling. Expand
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
It is found that, far from playing an inhibitory role during T cell activation, Rap1A positively influences T cells by augmenting lymphocyte responses and directing integrin activation. Expand
LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain
Methods of leukocyte stimulation that cause Ca2+ fluxes induce LFA-1 adhesion by regulation of calpain activity are proposed, suggesting a mechanism whereby engagement of the TCR could promote adhesion strengthening at an early stage of interaction with an antigen-presenting cell. Expand
T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1.
This study compares two well known protocols for inducing T cell LFA-1 mediated adhesion to intercellular adhesion molecule-1 (ICAM)-1 and uses a third method by stimulation of T cells through the TCR/CD3 complex. Expand
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
GDF-15 is the first cytokine identified as an inhibitor of PMN recruitment by direct interference with chemokine signaling and integrin activation, and loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction. Expand
T-cell integrins: more than just sticking points
T-cell integrins can also signal, and the pathways dedicated to the migratory activity of T cells have been the most investigated so far. Expand