• Publications
  • Influence
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation andExpand
  • 3,470
  • 259
  • PDF
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.
VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed inExpand
  • 1,086
  • 37
  • PDF
A Probabilistic Functional Network of Yeast Genes
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained byExpand
  • 317
  • 24
  • PDF
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.
An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated culturedExpand
  • 1,655
  • 23
  • PDF
Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.
Eosinophil accumulation is a distinctive feature of lung allergic inflammation. Here, we have used a mouse model of OVA (ovalbumin)-induced pulmonary eosinophilia to study the cellular and molecularExpand
  • 469
  • 21
  • PDF
Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation.
The recruitment of mononuclear leukocytes and formation of intimal macrophage-rich lesions at specific sites of the arterial tree are key events in atherogenesis. Inducible endothelial cell adhesionExpand
  • 617
  • 19
Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap
The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient TExpand
  • 289
  • 19
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.
Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is one of the key events in early atherogenesis. We have examined the effect of lysophosphatidylcholine (lyso-PC;Expand
  • 802
  • 15
  • PDF
NF-κB: pivotal mediator or innocent bystander in atherogenesis?
Atherosclerosis and its clinical manifestations of heart attack, stroke, and peripheral vascular insufficiency are a major cause of morbidity and mortality among both men and women. Multiple riskExpand
  • 640
  • 14
  • PDF
Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.
Vascular cell adhesion molecule-1 (VCAM-1) is expressed on vascular endothelium in a variety of inflammatory conditions and mediates leukocyte recruitment from blood into tissues. In this study weExpand
  • 388
  • 14
  • PDF