Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.

@article{Lefort2012DistinctRF,
  title={Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.},
  author={Craig T Lefort and Jan Rossaint and Markus Moser and Brian G Petrich and Alexander Zarbock and Susan J. Monkley and David R. Critchley and Mark H Ginsberg and Reinhard F{\"a}ssler and Klaus Ley},
  journal={Blood},
  year={2012},
  volume={119 18},
  pages={4275-82}
}
In inflammation, neutrophils and other leukocytes roll along the microvascular endothelium before arresting and transmigrating into inflamed tissues. Arrest requires conformational activation of the integrin lymphocyte function-associated antigen-1 (LFA-1). Mutations of the FERMT3 gene encoding kindlin-3 underlie the human immune deficiency known as leukocyte adhesion deficiency-III. Both kindlin-3 and talin-1, another FERM domain-containing cytoskeletal protein, are required for integrin… CONTINUE READING
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