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Regulating cell migration: calpains make the cut
The calpain family of proteases has been implicated in cellular processes such as apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of migration, including:Expand
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Integrins in cell migration.
Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitroExpand
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Integrins in cell migration.
Integrins are cell-surface adhesion receptors that play a central role in regulating cell migration by mediating interactions between the extracellular matrix and the actin cytoskeleton. SubstantialExpand
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Calpain-mediated proteolysis of talin regulates adhesion dynamics
Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of theExpand
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Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.
Neutrophil chemotaxis to sites of inflammation is a critical process during normal immune responses to tissue injury and infection and pathological immune responses leading to chronic inflammation.Expand
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Lyn is a redox sensor that mediates leukocyte wound attraction in vivo
Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type of ‘unhealed wound’—generate hydrogen peroxide (H2O2) through an NADPH oxidase (NOX). This extracellular H2O2Expand
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Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.
Cell polarity is crucial for directed migration. Here we show that phosphoinositide 3-kinase (PI(3)K) mediates neutrophil migration in vivo by differentially regulating cell protrusion and polarity.Expand
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Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish.
In tuberculosis, infecting mycobacteria are phagocytosed by macrophages, which then migrate into deeper tissue and recruit additional cells to form the granulomas that eventually contain infection.Expand
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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
Focal adhesion kinase (FAK) is important for breast cancer progression and invasion and is necessary for the dynamic turnover of focal adhesions. However, it has not been determined whether FAK alsoExpand
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Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases.
Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integrin-mediated adhesion to high fibronectin concentrations induces a stop signal for cell migrationExpand
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