Dihydropyrimidine dehydrogenase

Known as: Dihydrothymine Dehydrogenase (NADP), DHPDHase, Dihydrouracil Dehydrogenase (NADP) 
Dihydropyrimidine dehydrogenase [NADP(+)] (1025 aa, ~111 kDa) is encoded by the human DPYD gene. This protein is involved in the degradation of… (More)
National Institutes of Health

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21 relations
Aldehyde Dehydrogenase MitochondrialBeta-Alanine Metabolism PathwayCatabolic ProcessDPYD gene
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Papers overview

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2014
2014
Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity.
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of the uracil catabolic pathway, being critically… (More)
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Review
2003
Review
2003
5-fluorouracil and dihydropyrimidine dehydrogenase.
Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme of (fluorinated) pyrimidine degradation that plays a significant… (More)
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Highly Cited
2001
Highly Cited
2001
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency…
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it… (More)
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Highly Cited
2000
Highly Cited
2000
Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues.
Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme that metabolizes 5'-deoxy-5-fluorouridine (5'-dFUrd, doxifluridine… (More)
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1999
1999
Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer.
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for 5-fluorouracil catabolism. In this study, both the… (More)
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1999
1999
Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance.
DPD (also known as dihydrouracil dehydrogenase, dihydrothymine dehydrogenase, and uracil reductase; EC 1.3.1.2) is the initial… (More)
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1998
1998
Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours.
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for degradation of 5-fluorouracil (5-FU). DPD activity is… (More)
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Highly Cited
1996
Highly Cited
1996
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… (More)
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1993
1993
Dihydropyrimidine dehydrogenase activity in cancer patients.
Dihydropyrimidine dehydrogenase (DPD) is the major catabolic enzyme of pyrimidines and fluoropyrimidines. The clinical course of… (More)
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1992
1992
Purification and characterization of dihydropyrimidine dehydrogenase from human liver.
Although dihydropyrimidine dehydrogenase has been purified to varying degrees from several species, very little is known about… (More)
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