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Dihydropyrimidine dehydrogenase

Known as: Dihydrothymine Dehydrogenase (NADP), DHPDHase, Dihydrouracil Dehydrogenase (NADP) 
Dihydropyrimidine dehydrogenase [NADP(+)] (1025 aa, ~111 kDa) is encoded by the human DPYD gene. This protein is involved in the degradation of… 
National Institutes of Health

Related topics

Related topics

21 relations
Aldehyde Dehydrogenase MitochondrialBeta-Alanine Metabolism PathwayCatabolic ProcessDPYD gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer
Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the… 
Highly Cited
2002
Highly Cited
2002
Predicting 5-FU sensitivity using human colorectal cancer specimens: comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro…
Abstract.Background: In tumor cells, the enzyme orotate phosphoribosyl transferase (OPRT) contributes to 5-fluorouracil (5-FU… 
2002
2002
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.
BACKGROUND The role of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) enzyme activities in tumor progression… 
Highly Cited
1993
Highly Cited
1993
Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines…
1980
1980
Biochemical commitment to replication in cancer cells.
Highly Cited
1977
Highly Cited
1977
Biochemical strategy of the genome as expressed in regulation of pyrimidine metabolism.
Highly Cited
1970
Highly Cited
1970
Control of gene expression in carbohydrate, pyrimidine and DNA metabolism.
1964
1964
SYNTHETIC PYRIMIDINES AS INHIBITORS OF URACIL AND THYMINE DEGRADATION BY RAT-LIVER SUPERNATANT.
1962
1962
The relation between uracil-catabolizing enzymes and rate of rat liver regeneration.
Highly Cited
1957
Highly Cited
1957
Studies on the biosynthesis of bacterial and viral pyrimidines. II. Derivatives of dihydrocytosine.
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