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Dihydropyrimidine dehydrogenase
Known as:
Dihydrothymine Dehydrogenase (NADP)
, DHPDHase
, Dihydrouracil Dehydrogenase (NADP)
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Dihydropyrimidine dehydrogenase [NADP(+)] (1025 aa, ~111 kDa) is encoded by the human DPYD gene. This protein is involved in the degradation of…
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National Institutes of Health
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Related topics
Related topics
21 relations
Aldehyde Dehydrogenase Mitochondrial
Beta-Alanine Metabolism Pathway
Catabolic Process
DPYD gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Uridine triacetate for lethal 5-FU toxicity due to dihydropyrimidine dehydrogenase (DPD) deficiency.
R. Borstel
,
J. O'neil
,
J. Saydoff
,
M. Bamat
2010
Corpus ID: 74452191
e13505 Background: The enzyme dihydropyrimidine dehydrogenase (DPD) catalyzes the first step in degradation of 5-fluorouracil…
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2005
2005
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine
H. Keizer
,
E. D. de Bruijn
,
U. Tjaden
,
E. De Clercq
Journal of Cancer Research and Clinical Oncology
2005
Corpus ID: 656940
The thymidine analogue (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVdUrd), which is an antiviral agent effective against herpes…
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2005
2005
Thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), ERCC1, & thymidine phosphorylase gene expression in primary & metastatic (met) colorectal cancer (CRC) tissue in patients (pts…
J. Grem
,
K. Uchida
,
D. Salonga
,
P. Danenberg
,
K. Danenberg
2005
Corpus ID: 74105257
3549 Background: Overexpression of TS/DPD & ERCC1 in tumor tissue have been associated with insensitivity to 5-FU and OX therapy…
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2004
2004
Verwertung von Pyrimidinderivaten durch Hydrogenomonas facilis
J. Krämer
,
H. Kaltwasser
Archiv für Mikrobiologie
2004
Corpus ID: 11363733
Summary35 mutant strains, unable to utilize uracil as a nitrogen source, were isolated from Hydrogenomonas facilis following…
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2004
2004
Verwertung von Pyrimidinderivaten durch Hydrogenomonas facilis
J. Krämer
,
H. Kaltwasser
Archiv für Mikrobiologie
2004
Corpus ID: 7490357
SummaryDihydrouracil, 3-ureidopropionate and β-alanine, intermediates involved in the reductive degradation of cytosine, were…
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2000
2000
A Novel One - Pot Synthesis of 3,4 - Dihydropyrimidine - 2(1H) -Ones by Catalyzed Ferric Chloride Hexahydrate
Ma Huai
,
L. Wan
2000
Corpus ID: 102314471
The syntheses of dihydropyrimidinones by a one - pot cyclocondensation of aldehydes,B - keto ester, and ureas ( 1 : 1 : 1 . 5…
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1987
1987
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
S. Fujii
Gan to kagaku ryoho. Cancer & chemotherapy
1987
Corpus ID: 43667426
2, 6-Dihydroxy-3-cyano pyridine (CNDP) was found from the study of inhibitory effects of pyrimidine and pyridine derivatives on 5…
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1985
1985
DIHYDROTHYMINE DEHYDROGENASE DEFICIENCY IN A FAMILY LEADING TO ELEVATED LEVELS OF URACIL AND THYMINE: 51
R. D. Abreu
,
J. Bakkeren
,
J. Braakhekke
,
F. Gabreëls
,
J. Maas
,
R. Sengers
Pediatric Research
1985
Corpus ID: 31706113
Recently we have reported about a seven year old girl, the second child of non-consanguineous parents, with dihydrothymine…
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1984
1984
Catabolism of exogenously supplied thymidine to thymine and dihydrothymine by platelets in human peripheral blood.
R. Pero
,
D. Johnson
,
A. Olsson
Cancer Research
1984
Corpus ID: 65097
The interference of platelets with the estimation of unscheduled DNA synthesis in human peripheral mononuclear leukocytes…
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1970
1970
Electron spin resonance of gamma-irradiated single crystal of dihydrouracil.
J. Herak
Journal of Chemical Physics
1970
Corpus ID: 42525671
Free radicals in gamma‐irradiated dihydrouracil have been identified as –C(5)H2–C(6)H–. Two sets of resonance lines due to two…
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