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Dihydropyrimidine dehydrogenase
Known as:
Dihydrothymine Dehydrogenase (NADP)
, DHPDHase
, Dihydrouracil Dehydrogenase (NADP)
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Dihydropyrimidine dehydrogenase [NADP(+)] (1025 aa, ~111 kDa) is encoded by the human DPYD gene. This protein is involved in the degradation of…
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National Institutes of Health
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Related topics
Related topics
21 relations
Aldehyde Dehydrogenase Mitochondrial
Beta-Alanine Metabolism Pathway
Catabolic Process
DPYD gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer
W. Ichikawa
,
Takehiro Takahashi
,
+5 authors
R. Hirayama
International Journal of Cancer
2004
Corpus ID: 25983129
Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the…
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Highly Cited
2002
Highly Cited
2002
Predicting 5-FU sensitivity using human colorectal cancer specimens: comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro…
K. Isshi
,
T. Sakuyama
,
+4 authors
Y. Maekawa
International Journal of Clinical Oncology
2002
Corpus ID: 35208769
Abstract.Background: In tumor cells, the enzyme orotate phosphoribosyl transferase (OPRT) contributes to 5-fluorouracil (5-FU…
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2002
2002
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.
Masanori Terashima
,
T. Irinoda
,
+9 authors
M. Fukushima
Anticancer Research
2002
Corpus ID: 28856978
BACKGROUND The role of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) enzyme activities in tumor progression…
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Highly Cited
1993
Highly Cited
1993
Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines…
F. Naguib
,
S. Soong
,
M. H. el Kouni
Biochemical Pharmacology
1993
Corpus ID: 27095370
1980
1980
Biochemical commitment to replication in cancer cells.
G. Weber
,
E. Oláh
,
M. Lui
,
H. Kizaki
,
D. Tzeng
,
E. Takeda
Advances in Enzyme Regulation
1980
Corpus ID: 2502421
Highly Cited
1977
Highly Cited
1977
Biochemical strategy of the genome as expressed in regulation of pyrimidine metabolism.
G. Weber
,
T. Shiotani
,
H. Kizaki
,
D. Tzeng
,
J. Williams
,
N. Gladstone
Advances in Enzyme Regulation
1977
Corpus ID: 44849995
Highly Cited
1970
Highly Cited
1970
Control of gene expression in carbohydrate, pyrimidine and DNA metabolism.
G. Weber
,
S. Queener
,
J. A. Ferdinandus
Advances in Enzyme Regulation
1970
Corpus ID: 43909754
1964
1964
SYNTHETIC PYRIMIDINES AS INHIBITORS OF URACIL AND THYMINE DEGRADATION BY RAT-LIVER SUPERNATANT.
H. Barrett
,
S. Munavalli
,
P. Newmark
Biochimica et Biophysica Acta
1964
Corpus ID: 34491142
1962
1962
The relation between uracil-catabolizing enzymes and rate of rat liver regeneration.
P. Fritzson
Journal of Biological Chemistry
1962
Corpus ID: 13269747
Highly Cited
1957
Highly Cited
1957
Studies on the biosynthesis of bacterial and viral pyrimidines. II. Derivatives of dihydrocytosine.
M. Green
,
S. Cohen
Journal of Biological Chemistry
1957
Corpus ID: 1928612
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