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Enzymes of uracil catabolism in normal and neoplastic human tissues.
TLDR
Dihydropyrimidinase, on the other hand, is highly active in all solid tumors studied but not in their normal counterparts; therefore, it is suggested that dihydropyrimide can serve as a good marker of tumorigenicity as well as a target for cancer chemotherapy of human solid tumors.
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
TLDR
Kinetic parameters and inhibition studies were used to ascertain the binding affinity, substrate specificity, and contributions of UrdPase and dThdPase to the phosphorolysis of the various nucleosides in the 3 tissues and it appears that the specificities of human hepatic pyrimidine nucleoside phosphorylases are distinct from those from extrahepatic tissues.
The Adenosine Transporter of Toxoplasma gondii
TLDR
The combination of genetic and biochemical studies demonstrates that TgAT is the sole functional adenosine transporter in T. gondii and a rational target for therapeutic intervention.
Synthesis of a new class of uridine phosphorylase inhibitors
A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid. Among them, 1-[(2-hydroxyethoxy)methyl]-5-)(m--benzyloxy)benzylbarbituric acid (37, BBBA) is the most
Three purine auxotrophic loci on the second chromosome of Drosophila melanogaster
TLDR
Three second-chromosomal loci of Drosophila melanogaster have been isolated, mapped, and shown to be purine nucleoside auxotrophs, which are supplementable with adenine, adenosine, and inosine.
Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
TLDR
The synthesis of new analogues of BTI as subversive substrates for T. gondii adenosine kinase were synthesized starting from tribenzoyl protected d-ribose using a polymer-supported trityl group at the 5'-position.
Pyrimidine salvage pathways in adult Schistosoma mansoni.
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