Enzymes of uracil catabolism in normal and neoplastic human tissues.
- F. Naguib, M. H. el Kouni, S. Cha
- Biology, ChemistryCancer Research
- 1 November 1985
Dihydropyrimidinase, on the other hand, is highly active in all solid tumors studied but not in their normal counterparts; therefore, it is suggested that dihydropyrimide can serve as a good marker of tumorigenicity as well as a target for cancer chemotherapy of human solid tumors.
5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase.
- J. G. Niedzwicki, S. Chu, M. H. el Kouni, E. C. Rowe, S. Cha
- Chemistry, BiologyBiochemical Pharmacology
- 15 May 1982
Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases.
- J. G. Niedzwicki, M. H. el Kouni, S. Chu, S. Cha
- Chemistry, BiologyBiochemical Pharmacology
- 1 February 1983
Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase.
- J. G. Niedzwicki, M. H. el Kouni, S. Chu, S. Cha
- Chemistry, BiologyBiochemical Pharmacology
- 1 August 1981
The Adenosine Transporter of Toxoplasma gondii
- C. Chiang, N. Carter, C. M. Wilson
- BiologyJournal of Biological Chemistry
- 3 December 1999
The combination of genetic and biochemical studies demonstrates that TgAT is the sole functional adenosine transporter in T. gondii and a rational target for therapeutic intervention.
Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
- W. Bu, E. Settembre, M. H. el Kouni, S. Ealick
- Chemistry, BiologyActa Crystallographica Section D: Biological…
- 1 July 2005
These structures explain the basis of inhibition for this series of acyclouridine analogs and suggest possible additional avenues for future drug-design efforts and can be extended to design inhibitors of human UP, for which no X-ray structure is available.
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
- M. H. el Kouni, M. E. el Kouni, F. Naguib
- Biology, ChemistryCancer Research
- 15 August 1993
Kinetic parameters and inhibition studies were used to ascertain the binding affinity, substrate specificity, and contributions of UrdPase and dThdPase to the phosphorolysis of the various nucleosides in the 3 tissues and it appears that the specificities of human hepatic pyrimidine nucleoside phosphorylases are distinct from those from extrahepatic tissues.
Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus.
- W. J. Sullivan, C. Chiang, D. Roos
- BiologyMolecular and biochemical parasitology (Print)
- 20 September 1999
Potential chemotherapeutic targets in the purine metabolism of parasites.
- M. H. el Kouni
- BiologyPharmacology and Therapeutics
- 2003
Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii.
- M. H. Iltzsch, S. S. Uber, K. O. Tankersley, M. H. el Kouni
- Chemistry, BiologyBiochemical Pharmacology
- 17 May 1995
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