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Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).
TLDR
This is the first report showing that a marked therapeutic response was achieved against rapidly growing hepatoma 3924A by treatment with a single anti-metabolite, and tiazofurin treatment resulted in significant anti-tumor activity in rats inoculated with hepatoma3924A. Expand
Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.
TLDR
The pattern of deoxynucleoside triphosphate pools in rapidly growing differentiating and regenerating liver and in hepatoma 3924A shows that the concentrations of these key precursors of DNA biosynthesis are particularly increased in the tumor, and this may confer selective advantages on the neoplastic cells. Expand
Effects of acivicin and dipyridamole on hepatoma 3924A cells.
TLDR
Addition of a combination of cytidine, deoxycytidine, and guanosine, at an optimal concentration of 80 microM each, protected the hepatoma cells from the growth-inhibitory action of the antiglutamine drug, acivicin. Expand
Biochemical commitment to replication in cancer cells.
TLDR
The results are in line with earlier ones in this Laboratory on solid tumors indicating an integrated imbalance of the key enzymes of pyrimidine, purine and carbohydrate metabolism that should confer selective advantages to cancer cells. Expand
Salvage capacity of hepatoma 3924A and action of dipyridamole.
TLDR
Combination chemotherapy of inhibitors of the de novo pathways with an inhibitor of the salvage pathways (dipyridamole) should impact on understanding of the contribution of salvage pathways and provide a rational basis for successful combination chemotherapy of neoplastic diseases. Expand
Biochemical programs of slowly and rapidly growing human colon carcinoma xenografts.
TLDR
The results indicate the applicability of the molecular correlation concept to human colon neoplasia and should be helpful in the rational design of enzyme pattern-targeted chemotherapy of colon tumors. Expand
Enzyme pattern-directed chemotherapy. Effects of antipyrimidine combinations on the ribonucleotide content of hepatomas.
TLDR
Using combinations of three antipyrimidine drugs, chosen on the basis of expected antihepatoma selectivity, the effects on pyrimidine ribonucleotide pools in rat hepatomas and host livers were examined and d -galactosamine-induced depletion of UTP in liver and hepatoma 8999 was restored. Expand
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
TLDR
Results are consistent with an interpretation that acivicin acts either as a tight-binding inhibitor or as an inactivator through alkylation of the enzymes of glutamine utilization, and the synergistic biological results of combination chemotherapy with ac civicin and actinomycin can be accounted for. Expand
Enzymology of human colon tumors.
TLDR
The reprogramming of gene expression in human Colon tumor provides an increased capacity for biosynthesis of pyrimidines and ribose 5-phosphate, and for utilization of the glycolytic pathway and of galactose, which should confer selective advantages to the human colon tumor cells. Expand
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