• Publications
  • Influence
Effects of polyamines on the structure and reactivity of tRNA.
  • T. Sakai, S. Cohen
  • Biology, Medicine
  • Progress in nucleic acid research and molecular…
  • 1976
TLDR
The chapter discusses a recent NMR study that showed that there is indeed a unique binding site for ethidium bromide in yeast tRNA Phe located at the base of the amino acid acceptor arm, near the postulated site for spermidine binding. Expand
Variant genotypes of FcgammaRIIIA influence the development of Kaposi's sarcoma in HIV-infected men.
TLDR
It is found that the frequency of polymorphic forms of the low affinity FcgammaRIIIA genotype exerts a significant influence on susceptibility to or protection from Kaposi's sarcoma in HIV-infected men with KS. Expand
STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI.
  • S. Cohen, H. Barner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1954
The synthesis of bacterial viruses; the synthesis of nucleic acid and protein in Escherichia coli B infected with T2r + bacteriophage.
  • S. Cohen
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1 May 1948
TLDR
The data show that cells infected with Tzr+ do not appear to synthesize or metabolize RNA, despite a rapid synthesis’ of DNA, and it appears unlikely, therefore, that RNA is a constituent of either virus. Expand
Enzymatic conversion of L-fucose to L-fuculose.
  • M. Green, S. Cohen
  • Medicine, Biology
  • The Journal of biological chemistry
  • 1 April 1956
Protein synthesis and RNA turnover in a pyrimidine-deficient bacterium.
TLDR
Despite the absence of net nucleic acid synthesis in pyrimidine deficiency, a fraction of the RNA was found to have a marked turnover in which preformed uracil of RNA was released and reincorporated with newly formed ribose generated in the presence of glucose-14C. Expand
Penetration of mouse fibroblasts by the 5'-phosphate of 9-beta-D-arabinofuranosyladenine and incorporation of the nucleotide into DNA.
TLDR
Results suggest that small amounts of araAMP penetrated the cell as an intact nucleotide, were further phosphorylated to the triphosphate, and subsequently incorporated in internucleotide linkage into DNA. Expand
Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.
  • S. Cohen, C. Li, +4 authors D. Cohen
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 14 September 1999
TLDR
It is proposed that Tat-induced suppression cripples immune surveillance to HIV infection, and a method to preserve immunogenicity while inactivating Tat immunosuppression through oxidation is reported, which advances the use of oxidized Tat as a component of an anti-HIV vaccine. Expand
THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS IN NORMAL AND PHAGE-INFECTED THYMINELESS STRAINS OF ESCHERICHIA COLI.
TLDR
During the study of strains of E. coli deficient in the ability to synthesize thymine, uracil, and an amino acid, compared nucleic acid syntheses in variously deficient cultures, it was supposed that the :meager RNA synthesis was that of messenger RNA, which was affected by a competition between DNA and RNA synthesis for a common template. Expand
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