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Dexetimide

Known as: dextro-Benzetimide, (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-, dextro Benzetimide 
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (6)

4-bromodexetimide4-iododexetimideN-methyl-4-iododexetimideSpasmentral

Broader (3)

Antiparkinson AgentsMuscarinic AntagonistsParasympatholytics
BenzetimideIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1992
Highly Cited
1992
Activation of T84 cell chloride channels by carbachol involves a phosphoinositide-coupled muscarinic M3 receptor.
1989
1989
In vivo cystometrogram studies in urethane-anesthetized and conscious guinea pigs.
1987
1987
[3H]AF-DX 116 labels subsets of muscarinic cholinergic receptors in rat brain and heart.
Highly Cited
1985
Highly Cited
1985
The muscarinic receptor of chick embryo cells: correlation between ligand binding and calcium mobilization
In this report we characterize muscarinic cholinergic receptor on embryonic cells. We established dose-response curves by… 
1984
1984
Characterization of muscarinic cholinergic receptors on rat pancreatic acini by N-[3H]methylscopolamine binding. Their relationship with calcium 45 efflux and amylase secretion.
1984
1984
Differentiation between ligand trapping into intact cells and binding on muscarinic receptors.
Highly Cited
1981
Highly Cited
1981
In vivo characterization of myocardium muscarinic receptors by positron emission tomography.
Highly Cited
1980
Highly Cited
1980
Muscarinic receptor binding in rat brain using the agonist, [3H]cis methyldioxolane.
Highly Cited
1979
Highly Cited
1979
STEREOSPECIFIC IN VlTRO BINDING OF [3H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS
A binding assay for muscarinic cholinergic receptors has been developed using labelled dexetimide as ligand and a filtration… 
1976
1976
Alteration in the action of cholinergic and anti cholinergic drugs after chronic haloperidol: indirect evidence for cholinergic hyposensitivity.
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