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Dexetimide

Known as: dextro-Benzetimide, (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-, dextro Benzetimide 
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (6)

4-bromodexetimide4-iododexetimideN-methyl-4-iododexetimideSpasmentral
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Broader (3)

Antiparkinson AgentsMuscarinic AntagonistsParasympatholytics
BenzetimideIn Bloodagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Demonstration of a reduction in muscarinic receptor binding in early Alzheimer's disease using iodine-123 dexetimide single-photon emission tomography
Decreased muscarinic receptor binding has been suggested in single-photon emission tomography (SPET) studies of Alzheimer's… 
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1998
1998
Locomotor Stereotypy Produced by Dexbenzetimide and Scopolamine Is Reduced by SKF 83566, Not Sulpiride
Like amphetamine, scopolamine produces locomotor stereotypy (repetitive routes of locomotion) in an open field. To determine… 
Highly Cited
1988
Highly Cited
1988
Synthesis of radiotracers for studying muscarinic cholinergic receptors in the living human brain using positron emission tomography: [11C]dexetimide and [11C]levetimide.
Dexetimide (Fig. 1a), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. 1b), its pharmacologically… 
Highly Cited
1988
Highly Cited
1988
Effects of Antagonists on Putative Histamine Receptors in the First Visual Neuropile of the Housefly (Musca Domestica)
Summary Intracellular recordings were made from the large monopolar cells (LMCs), which are the cells postsynaptic to… 
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1985
1985
The muscarinic receptor of chick embryo cells: correlation between ligand binding and calcium mobilization
In this report we characterize muscarinic cholinergic receptor on embryonic cells. We established dose-response curves by… 
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Highly Cited
1983
Highly Cited
1983
Purification of muscarinic acetylcholine receptors by affinity chromatography.
Calf forebrain homogenates contain 2.8 pM muscarinic acetylcholine receptors per mg of protein. [3H]Antagonist saturation binding… 
Highly Cited
1979
Highly Cited
1979
STEREOSPECIFIC IN VlTRO BINDING OF [3H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS
A binding assay for muscarinic cholinergic receptors has been developed using labelled dexetimide as ligand and a filtration… 
1979
1979
CHARACTERIZATION AND SUBCELLULAR LOCALIZATION OF BRAIN MUSCARINIC RECEPTORS LABELLED IN VIVO BY [3H]DEXETIMIDE
Abstract— [3H]Dexetimide specifically labels brain muscarinic receptors in vivo. After i.v. injection of labelled drug into rats… 
1973
1973
Dexetimide, a useful tool in acetylcholine-receptor localization.
Abstract Binding of the anticholinergic agent 3 H-dexetimide, the active isomer of (±)-benzetimide, to subcellular fractions of… 
1971
1971
The Absolute Configuration and Crystal Structure of the Anticholinergic Drug Dexbenzetimide
THE pharmacological activity of (±) benzetimide (Fig. 1) ((±)-1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)-piperidine HCl), a… 
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