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Dexetimide

Known as: dextro-Benzetimide, (3,4'-Bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)-, dextro Benzetimide 
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
National Institutes of Health

Papers overview

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2004
2004
Decreased muscarinic receptor binding has been suggested in single-photon emission tomography (SPET) studies of Alzheimer's… Expand
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Highly Cited
1988
Highly Cited
1988
Dexetimide (Fig. 1a), a potent muscarinic cholinergic receptor antagonist, and levetimide (Fig. 1b), its pharmacologically… Expand
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Highly Cited
1988
Highly Cited
1988
Summary Intracellular recordings were made from the large monopolar cells (LMCs), which are the cells postsynaptic to… Expand
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1985
1985
In this report we characterize muscarinic cholinergic receptor on embryonic cells. We established dose-response curves by… Expand
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Highly Cited
1983
Highly Cited
1983
Calf forebrain homogenates contain 2.8 pM muscarinic acetylcholine receptors per mg of protein. [3H]Antagonist saturation binding… Expand
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Highly Cited
1981
Highly Cited
1981
Abstract The feasibility of studying myocardium muscarinic receptors, non invasively, in a “live” being can be demonstrated using… Expand
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Highly Cited
1979
Highly Cited
1979
A binding assay for muscarinic cholinergic receptors has been developed using labelled dexetimide as ligand and a filtration… Expand
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1979
1979
Abstract— [3H]Dexetimide specifically labels brain muscarinic receptors in vivo. After i.v. injection of labelled drug into rats… Expand
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1973
1973
Abstract Binding of the anticholinergic agent 3 H-dexetimide, the active isomer of (±)-benzetimide, to subcellular fractions of… Expand
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1971
1971
THE pharmacological activity of (±) benzetimide (Fig. 1) ((±)-1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)-piperidine HCl), a… Expand
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