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Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.
For a new antiserotonergic agent, R 41 468 and 13 reference compounds with alleged antiserotonergic activity, the receptor binding profile is reported, comprising Ki-values measured in ten differentExpand
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Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist.
In vitro and in vivo receptor-binding properties of the new serotonin antagonist, ritanserin, are reported. In in vitro binding assays, ritanserin shows high affinity binding to serotonin-S2 sites inExpand
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Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
We describe here the pharmacological properties of RP 67580 [(3aR,7aR)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] perhydroisoindol-4-one], a nonpeptide antagonist of substance P (SP). InExpand
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Two populations of neurotensin binding sites in murine brain: discrimination by the antihistamine levocabastine reveals markedly different radioautographic distribution.
Monoiodo-[125I-Tyr3]neurotensin (NT) bound to a high affinity, low capacity binding component and a lower affinity, high capacity component in rat brain synaptic membranes. The antihistamine H1 agentExpand
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Different postnatal ontogeny of two [3H]neurotensin binding sites in rat brain
Two distinct neurotensin binding sites have been identified in rat brain: the NT1-acceptor site (levocabastine-sensitive) and the NT2-receptor site. In rat forebrain, NT2-receptors were present atExpand
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Spiperone: a ligand of choice for neuroleptic receptors. 3. Subcellular distribution of neuroleptic drugs and their receptors in various rat brain areas.
Abstract Tissue fractionation was used as an analytical tool to study in various rat brain regions the subcellular distribution of the neuroleptic receptor and labeled neuroleptics previouslyExpand
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Different Subcellular Localization of Neurotensin‐Receptor and Neurotensin‐Acceptor Sites in the Rat Brain Dopaminergic System
Abstract: The subcellular localization of neurotensin‐receptor sites (NT2 sites) and neurotensin‐acceptor sites (NT1 sites) was studied in rat caudate‐putamen by isopycnic centrifugation in sucroseExpand
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Retrograde axonal transport of neurotensin in rat nigrostriatal dopaminergic neurons. Modulation during ageing and possible physiological role.
Biochemical and anatomical data are reported which demonstrate for the first time the existence of a retrograde axonal transport process for a neuropeptide, neurotensin, in rat brain. NeurotensinExpand
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Axoplasmic transport of muscarinic receptors
The reality of axoplasmic transport is widely accepted; various neurotransmitters1–3, enzymes2–4, labelled proteins5 and peptides6 are known to move rapidly along the axons of different nerve fibres.Expand
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