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Activation of memory circuits during cue-elicited cocaine craving.
TLDR
Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe, and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
TLDR
It is established that NO mediates the neurotoxicity of glutamate and Hemoglobin, which complexes NO, prevents neurotoxic effects of both N-methyl-D-aspartate and sodium nitroprusside.
Decision-making in a Risk-taking Task: A PET Study
Brain metabolic changes during cigarette craving.
TLDR
Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving, similar to findings with other addictive substances.
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine
TLDR
MRI-based maps suggest that chronic methamphetamine abuse causes a selective pattern of cerebral deterioration that contributes to impaired memory performance, and brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury.
Frontoparietal cortical activity of methamphetamine‐dependent and comparison subjects performing a delay discounting task
TLDR
Apparent inefficiency of cortical processing related to decision‐making in MA abusers may contribute to the neural basis of enhanced delay discounting by this population, but other factors remain to be identified.
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.
TLDR
The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions.
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