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DIABLO gene

Known as: diablo IAP-binding mitochondrial protein, DIABLO, FLJ25049 
This gene plays a role in the positive regulation of apoptosis.
National Institutes of Health

Related topics

Related topics

7 relations
ApoptosisCaspase ActivationCaspase-Dependent ApoptosisDIABLO protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of smac/DIABLO from the mitochondria
The synergistic interaction between proteasome inhibitors and tumor necrosis factor (TNF)-related apoptosis-inducing ligand… 
2007
2007
A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.
2006
2006
Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c
We have characterised the apoptotic defects in cells null for cytochrome c (cyt c−/−). Such cells treated with staurosporine (STS… 
Highly Cited
2005
Highly Cited
2005
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.
Highly Cited
2004
Highly Cited
2004
Bax Mediates the Apoptosis-Sensitizing Effect of Maspin
Maspin, a serine protease inhibitor (serpin), can suppress tumor growth and metastasis in vivo and tumor cell motility and… 
Highly Cited
2004
Highly Cited
2004
Dynamic changes of the anti‐ and pro‐apoptotic proteins Bcl‐w, Bcl‐2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats
The anti‐apoptotic proteins Bcl‐w and Bcl‐2 and the pro‐apoptotic protein Bax may mediate cell death or survival via regulation… 
2004
2004
Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis*
Grim is a Drosophila inhibitor of apoptosis (IAP) antagonist that directly interferes with inhibition of caspases by IAPs… 
2003
2003
A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.
Highly Cited
2002
Highly Cited
2002
Generation and Characterization of Smac/DIABLO-Deficient Mice
ABSTRACT The mitochondrial proapoptotic protein Smac/DIABLO has recently been shown to potentiate apoptosis by counteracting the… 
Highly Cited
2002
Highly Cited
2002
Promotion of Photodynamic Therapy-Induced Apoptosis by the Mitochondrial Protein Smac/DIABLO: Dependence on Bax¶
Abstract Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage… 
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