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Caspase Activation

Known as: activation of caspase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process 
Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface… 
National Institutes of Health

Related topics

Related topics

29 relations
APAF1 protein, humanActivated Caspase-3BBC3 geneBBC3 wt Allele

Broader (1)

Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Apoptotic and nonapoptotic caspase functions in animal development.
A developing animal is exposed to both intrinsic and extrinsic stresses. One stress response is caspase activation. Caspase… 
Highly Cited
2008
Highly Cited
2008
Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis.
Highly Cited
2005
Highly Cited
2005
Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo
Tumor necrosis factor related apoptosis‐inducing ligand/Apo2 ligand (TRAIL/Apo‐2L) is a novel anticancer agent, capable of… 
Highly Cited
2004
Highly Cited
2004
The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death.
Highly Cited
2002
Highly Cited
2002
Activation of Caspase-9 Is Required for UV-induced Apoptosis of Human Keratinocytes*
UV radiation from the sun activates both the membrane death receptor and the intrinsic or mitochondrial apoptotic signaling… 
Highly Cited
2001
Highly Cited
2001
Blocking caspase-activated apoptosis improves contractility in failing myocardium.
Cardiac myocyte apoptosis has been demonstrated in end-stage failing human hearts. The therapeutic utility of blocking apoptosis… 
Highly Cited
2000
Highly Cited
2000
Mechanism of nitric oxide‐induced apoptosis in human neuroblastoma SH‐SY5Y cells
Highly Cited
1999
Highly Cited
1999
Cascades of Mammalian Caspase Activation in the YeastSaccharomyces cerevisiae *
Caspases (aspartate-specific cysteine proteases) play a critical role in the execution of the mammalian apoptotic program. To… 
Highly Cited
1999
Highly Cited
1999
Early induction of apoptosis in androgen‐independent prostate cancer cell line by FTY720 requires caspase‐3 activation
We previously reported that FTY720, a metabolite from Isaria sinclairii, induced some cancer cells to undergo apoptosis, and that… 
Highly Cited
1998
Highly Cited
1998
U937 apoptotic cell death by nitric oxide: Bcl-2 downregulation and caspase activation.
Upon treatment with NO-releasing compounds such as S-nitrosoglutathione or spermine NO, human myeloid leukemia U937 cells undergo… 
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