Caspase Activation

Known as: activation of caspase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process 
Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface… (More)

Topic mentions per year

Topic mentions per year

1989-2017
010020030019892017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Studies of post-mortem tissue have shown that the location of fibrillar tau deposits, called neurofibrillary tangles (NFT… (More)
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Highly Cited
2003
Highly Cited
2003
Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-step proteolytic cascade. Existing data… (More)
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Highly Cited
2002
Highly Cited
2002
Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 (and caspase-11 in mice), but… (More)
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Highly Cited
2000
Highly Cited
2000
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… (More)
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Highly Cited
2000
Highly Cited
2000
Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase… (More)
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Highly Cited
2000
Highly Cited
2000
Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive… (More)
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… (More)
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Highly Cited
1998
Highly Cited
1998
Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells… (More)
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Highly Cited
1998
Highly Cited
1998
Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the antiapoptotic mechanism of Survivin… (More)
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