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Caspase Activation

Known as: activation of caspase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process 
Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Apoptosis shapes development and differentiation, has a key role in tissue homeostasis, and is deregulated in cancer. In most… Expand
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Highly Cited
2009
Highly Cited
2009
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like… Expand
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Review
2003
Review
2003
The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most… Expand
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Highly Cited
2003
Highly Cited
2003
Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-step proteolytic cascade. Existing data… Expand
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Highly Cited
2000
Highly Cited
2000
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… Expand
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Review
1999
Review
1999
Apoptosis is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of… Expand
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… Expand
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Highly Cited
1998
Highly Cited
1998
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… Expand
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Highly Cited
1998
Highly Cited
1998
Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the antiapoptotic mechanism of Survivin… Expand
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Highly Cited
1998
Highly Cited
1998
Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells… Expand
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