Skip to search formSkip to main contentSkip to account menu

APAF1 protein, human

Known as: APAF1 Protein, Apoptotic Protease Activating Factor 1, apoptotic protease activating factor, human 
Apoptotic protease-activating factor 1 (1248 aa, ~142 kDa) is encoded by the human APAF1 gene. This protein plays a role in protein-protein… 
National Institutes of Health

Related topics

Related topics

14 relations
APAF1 geneAlzheimer's Disease Pathway KEGGApoptosisApoptosis Promoter

Broader (1)

apoptotic protease-activating factor 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway
Myotube apoptosis occurs normally during muscle development and aging but it can lead to destruction of skeletal muscle in… 
Highly Cited
2007
Highly Cited
2007
Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent…
FUS1 is a novel tumor suppressor gene identified in human chromosome 3p21.3 region. Loss of expression and deficiency of… 
Highly Cited
2006
Highly Cited
2006
Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis
Apoptosis is a biological process relevant to human disease states that is strongly regulated through protein–protein complex… 
Highly Cited
2005
Highly Cited
2005
Methylation Silencing of the Apaf-1 Gene in Acute Leukemia
Apaf-1 is important for tumor suppression and drug resistance because it plays a central role in DNA damage–induced apoptosis… 
Highly Cited
2005
Highly Cited
2005
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.
Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells… 
Highly Cited
2004
Highly Cited
2004
5-aza-2′-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells
Treating lung cancer cell lines using low-dose 5-aza-2′-deoxycytidine (DAC) caused an accumulation of procaspase-9 through mRNA… 
Highly Cited
2003
Highly Cited
2003
Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia
Apaf-1 protein deficiency occurs in human leukaemic blasts and confers resistance to cytochrome-c-dependent apoptosis… 
Highly Cited
2001
Highly Cited
2001
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
The human leukemia cell lines K562, CEM, CEM/VLB(100), human leukemic blasts, and the bladder cancer J82 cell line have different… 
Highly Cited
2000
Highly Cited
2000
Genes with homology to mammalian apoptosis regulators identified in zebrafish
Programmed cell death (PCD) is an evolutionarily conserved mechanism of cellular demise developed by metazoans to delete cells… 
Review
1999
Review
1999
Postmitochondrial regulation of apoptosis during heart failure.
The biochemical basis for most of the morphological changes associated with apoptosis can be traced directly or indirectly to the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)