APAF1 protein, human

Known as: APAF1 Protein, Apoptotic Protease Activating Factor 1, apoptotic protease activating factor, human 
Apoptotic protease-activating factor 1 (1248 aa, ~142 kDa) is encoded by the human APAF1 gene. This protein plays a role in protein-protein… (More)
National Institutes of Health

Papers overview

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Review
2003
Review
2003
NOD (nucleotide-binding oligomerization domain) proteins are members of a family that includes the apoptosis regulator APAF1… (More)
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Review
2003
Review
2003
A newly discovered family of cytoplasmic proteins — the NALPs — has been implicated in the activation of caspase-1 by the Toll… (More)
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Review
2000
Review
2000
Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal… (More)
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Highly Cited
2000
Highly Cited
2000
In many types of apoptosis, the proapoptotic protein Bax undergoes a change in conformation at the level of the mitochondria… (More)
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Highly Cited
2000
Highly Cited
2000
The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can… (More)
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Review
2000
Review
2000
Caspases are a large family of evolutionarily conserved proteases found from Caenorhabditis elegans to humans. Although the first… (More)
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Highly Cited
2000
Highly Cited
2000
Bcl-2 and related proteins are key regulators of apoptosis or programmed cell death implicated in human disease including cancer… (More)
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Highly Cited
1998
Highly Cited
1998
Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian… (More)
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Highly Cited
1998
Highly Cited
1998
The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in… (More)
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