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APAF1 gene

Known as: APAF1, Apoptotic Protease Activating Factor 1 Gene, APAF-1 
This gene is involved in pro-apoptotic regulation through caspase interaction.
National Institutes of Health

Related topics

Related topics

5 relations
ACIN1 geneAPAF1 protein, humanApoptosisPositive Regulation of Apoptosis

Papers overview

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Highly Cited
2004
Highly Cited
2004
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
Histone deacetylase (HDAC) inhibitors can induce programmed cell death in cancer cells, although the underlying mechanism is… 
Highly Cited
2003
Highly Cited
2003
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
E2F1, a member of the E2F family of transcription factors, in addition to its established proliferative effect, has also been… 
Highly Cited
2002
Highly Cited
2002
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Apoptosis is an evolutionarily conserved cell suicide process executed by cysteine proteases (caspases) and regulated by the… 
Highly Cited
2002
Highly Cited
2002
Evolution of TNF Signaling Mechanisms JNK-Dependent Apoptosis Triggered by Eiger, the Drosophila Homolog of the TNF Superfamily
Review
2002
Review
2002
Apoptosomes: engines for caspase activation.
Highly Cited
2001
Highly Cited
2001
Apaf-1 is a transcriptional target for E2F and p53
Loss of function of the retinoblastoma protein, pRB, leads to lack of differentiation, hyperproliferation and apoptosis… 
Highly Cited
2001
Highly Cited
2001
Dimer formation drives the activation of the cell death protease caspase 9
A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal… 
Highly Cited
1999
Highly Cited
1999
Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
Traumatic spinal cord injury often results in complete loss of voluntary motor and sensory function below the site of injury. The… 
Highly Cited
1999
Highly Cited
1999
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
Here we identify a new gene, dark, which encodes a Drosophila homologue of mammalian Apaf-1 and Caenorhabditis elegans CED-4… 
Review
1998
Review
1998
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
Bcl-2 is the prototype of a class of oncogenes which regulates apoptosis. Bcl-2-related gene products with either death-promoting… 
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