APAF1 gene

Known as: APAF1, Apoptotic Protease Activating Factor 1 Gene, APAF-1 
This gene is involved in pro-apoptotic regulation through caspase interaction.
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Apoptosis is the term given to programmed cell death, which has been widely connected to a number of intracranial pathologies… (More)
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Highly Cited
2003
Highly Cited
2003
Mitochondrial outer-membrane permeabilization by pro-apoptotic Bcl-2 family members plays a crucial role in apoptosis induction… (More)
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Review
2003
Review
2003
Focal ischemia by middle cerebral artery occlusion (MCAO) results in necrosis at the infarct core and activation of complex… (More)
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Highly Cited
2003
Highly Cited
2003
Plants have evolved sophisticated defense mechanisms against pathogen infections, during which resistance (R) genes play central… (More)
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Review
2001
Review
2001
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization and activation of… (More)
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Highly Cited
1999
Highly Cited
1999
To elucidate the mechanism of activation of procaspase-9 by Apaf-1, we produced recombinant full-length Apaf-1 and purified it to… (More)
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Highly Cited
1998
Highly Cited
1998
The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of… (More)
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Highly Cited
1998
Highly Cited
1998
Recent studies indicate that Caenorhabditis elegans CED-4 interacts with and promotes the activation of the death protease CED-3… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in… (More)
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