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dMyc Transforms Cells into Super-Competitors
Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remainsExpand
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Evolution of TNF Signaling Mechanisms JNK-Dependent Apoptosis Triggered by Eiger, the Drosophila Homolog of the TNF Superfamily
Much of what we know about apoptosis in human cells stems from pioneering genetic studies in the nematode C. elegans. However, one important way in which the regulation of mammalian cell deathExpand
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Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
During the growth of Drosophila imaginal discs a process called ‘cell competition’ eliminates slow-proliferating but otherwise viable cells. We report here that cell competition requires the functionExpand
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Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cellExpand
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The brinker gradient controls wing growth in Drosophila
The Decapentaplegic (Dpp) morphogen gradient controls growth and patterning in the Drosophila appendages. There is recent evidence indicating that the Dpp gradient is converted into an inverseExpand
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Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche
Cell competition is a short-range cell-cell interaction leading to the proliferation of winner cells at the expense of losers, although either cell type shows normal growth in homotypic environments.Expand
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Is cell competition relevant to cancer?
  • E. Moreno
  • Medicine, Biology
  • Nature Reviews Cancer
  • 1 February 2008
Cell competition is a type of short-range cell–cell interaction described in Drosophila melanogaster, in which cells expressing different levels of a particular protein are able to discriminateExpand
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Caudal is the Hox gene that specifies the most posterior Drosophile segment
The homeobox gene caudal (cad) has a maternal embryonic function that establishes the antero–posterior body axis of Drosophila,. It also has a conserved, late embryonic and imaginal function relatedExpand
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Tissue Crowding Induces Caspase-Dependent Competition for Space
Summary Regulation of tissue size requires fine tuning at the single-cell level of proliferation rate, cell volume, and cell death. Whereas the adjustment of proliferation and growth has been widelyExpand
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“Fitness Fingerprints” Mediate Physiological Culling of Unwanted Neurons in Drosophila
BACKGROUND The flower gene has been previously linked to the elimination of slow dividing epithelial cells during development in a process known as "cell competition." During cell competition,Expand
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