Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

  title={Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury},
  author={Joe E Springer and Robert D. Azbill and Pamela E Knapp},
  journal={Nature Medicine},
Traumatic spinal cord injury often results in complete loss of voluntary motor and sensory function below the site of injury. The long-term neurological deficits after spinal cord trauma may be due in part to widespread apoptosis of neurons and oligodendroglia in regions distant from and relatively unaffected by the initial injury. The caspase family of cysteine proteases regulates the execution of the mammalian apoptotic cell death program. Caspase-3 cleaves several essential downstream… CONTINUE READING
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