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BBC3 wt Allele

Known as: PUMA, BCL2 Binding Component 3 wt Allele, FLJ42994 
Human BBC3 wild-type allele is located within 19q13.3-q13.4 and is approximately 12 kb in length. This allele, which encodes Bcl-2-binding component… 
National Institutes of Health

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7 relations
19q13.3-q13.4ApoptosisBBC3 geneBcl-2-Binding Component 3

Papers overview

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Highly Cited
2011
Highly Cited
2011
Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3
Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresses (for example, ionizing and… 
Highly Cited
2011
Highly Cited
2011
A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA[S]
Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in nonalcoholic fatty liver… 
Highly Cited
2010
Highly Cited
2010
PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01
Most targeted anticancer drugs are inhibitors of kinases that are aberrantly activated in cancer cells. However, the mechanisms… 
Highly Cited
2007
Highly Cited
2007
Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis
Oxidative stress has been implicated as a key trigger of neuronal apoptosis in stroke and neurodegenerative conditions such as… 
Highly Cited
2007
Highly Cited
2007
Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2
Taxanes have a broad spectrum of activity against various human cancers, including melanoma. In this study, we have examined the… 
2007
2007
NOXA and PUMA Expression Add to Clinical Markers in Predicting Biochemical Recurrence of Prostate Cancer Patients in a Survival Tree Model
Purpose: To assess the expression of proapoptotic NOXA and PUMA in prostate tissues and delineate their association with prostate… 
Highly Cited
2007
Highly Cited
2007
Apoptotic Actions of p53 Require Transcriptional Activation of PUMA and Do Not Involve a Direct Mitochondrial/Cytoplasmic Site of Action in Postnatal Cortical Neurons
Recent studies in non-neuronal cells have shown that the tumor suppressor p53 can promote cell death through a transcription… 
Highly Cited
2006
Highly Cited
2006
The Histidine Triad Protein Hint1 Triggers Apoptosis Independent of Its Enzymatic Activity*
Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor… 
Review
2003
Review
2003
No PUMA, no death: implications for p53-dependent apoptosis.
Highly Cited
1994
Highly Cited
1994
A search for consensus among model parameters reported for the PUMA 560 robot
The PUMA 560 robot is the white rat of robotics research - it has been studied and used in countless experiments over many years… 
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