Induction of PUMA-alpha and down-regulation of PUMA-beta expression is associated with benzo(a)pyrene-induced apoptosis in MCF-7 cells.

@article{Tampio2009InductionOP,
  title={Induction of PUMA-alpha and down-regulation of PUMA-beta expression is associated with benzo(a)pyrene-induced apoptosis in MCF-7 cells.},
  author={Marjo Tampio and Piia Markkanen and Katja A. Puttonen and Eveliina Hagelberg and Hannu I. Heikkinen and Kati Huhtinen and Jarkko Loikkanen and M. -R. Hirvonen and Kirsi H. V{\"a}h{\"a}kangas},
  journal={Toxicology letters},
  year={2009},
  volume={188 3},
  pages={214-22}
}
Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation. Although BP-induced apoptosis in rodent cells is known, it is still unclear in human cells. Here we have analyzed the effects of BP on p53 related apoptotic proteins, cell… CONTINUE READING