Skip to search formSkip to main contentSkip to account menu

Bcl-2-Binding Component 3

Known as: BBC3 Protein, PUMA, p53 Up-Regulated Modulator of Apoptosis 
Bcl-2-binding component 3 (193 aa, ~21 kDa) is encoded by the human BBC3 gene. This protein plays a role in the regulation of apoptosis.
National Institutes of Health

Related topics

Related topics

9 relations
ApoptosisBBC3 geneBBC3 wt AlleleCaspase Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia
The transcriptional regulator ecotropic viral integration site-1 (EVI-1) has mainly been studied for its role in myeloid… 
2013
2013
PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data
Penalized Multiple Regression (PMR) can be used to discover novel disease associations in GWAS datasets. In practice, proposed… 
Highly Cited
2011
Highly Cited
2011
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth
Aberrant Ras/Raf/MEK/ERK signaling is one of the most prevalent oncogenic alterations and confers survival advantage to tumor… 
2008
2008
Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*
Previously, using primary hepatocytes residing in early G1 phase, we demonstrated that expression of the cyclin-dependent kinase… 
Highly Cited
2007
Highly Cited
2007
Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent Manner*
Photodynamic therapy (PDT) of cancer is an alternative treatment for tumors resistant to chemo- and radiotherapy. It induces… 
Highly Cited
2007
Highly Cited
2007
Chemosensitization of head and neck cancer cells by PUMA
Head and neck squamous cell carcinoma (HNSCC) ranks the eighth most common cancer worldwide. The patients often present with… 
2006
2006
Inhibition of staurosporine-induced activation of the proapoptotic multidomain Bcl-2 proteins Bax and Bak by three invasive chlamydial species.
2005
2005
Cyclin-dependent Kinase Inhibitors Uncouple Cell Cycle Progression from Mitochondrial Apoptotic Functions in DNA-damaged Cancer Cells*
DNA damage results in transcriptional induction of p53 target genes, including the cyclin-dependent kinase (CDK) inhibitor… 
Highly Cited
2003
Highly Cited
2003
Differential Apoptotic Response to the Proteasome Inhibitor Bortezomib (VELCADETM, PS-341) in Bax-Deficient and p21-Deficient Colon Cancer Cells
Targeting the ubiquitin-proteasome pathway has emerged as a promising approach for treating cancer. Bortezomib (VELCADETM… 
1983
1983
The Dynamics of the PUMA Manipulator
Symbolic equations defining the effective joint inertias and gravity loading torques for the Unimate PUMA manipulator are derived… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)