Bcl-2-Binding Component 3

Known as: BBC3 Protein, PUMA, p53 Up-Regulated Modulator of Apoptosis 
Bcl-2-binding component 3 (193 aa, ~21 kDa) is encoded by the human BBC3 gene. This protein plays a role in the regulation of apoptosis.
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Normal cellular lifespan is contingent upon preserving outer mitochondrial membrane (OMM) integrity, as permeabilization promotes… (More)
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Review
2007
Review
2007
Impaired apoptosis is both critical in cancer development and a major barrier to effective treatment. In response to diverse… (More)
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Highly Cited
2006
Highly Cited
2006
Although the BCL-2 family constitutes a crucial checkpoint in apoptosis, the intricate interplay between these family members… (More)
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Review
2006
Review
2006
Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis. During the last ten years, specific… (More)
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Highly Cited
2006
Highly Cited
2006
The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here, we describe a previously unknown… (More)
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Highly Cited
2005
Highly Cited
2005
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of… (More)
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Highly Cited
2004
Highly Cited
2004
The E2F1 transcription factor is a critical downstream target of the tumor suppressor pRB. The retinoblastoma (RB) pathway is… (More)
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Highly Cited
2003
Highly Cited
2003
Apoptosis provoked by DNA damage requires the p53 tumor suppressor, but which of the many p53-regulated genes are required has… (More)
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Highly Cited
2003
Highly Cited
2003
Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The… (More)
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Highly Cited
2001
Highly Cited
2001
The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-inducible genes that play a role in… (More)
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