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Activated Caspase-3

Known as: Activated Caspase 3 
Activated caspase-3 (249 aa, ~29 kDa) is encoded by the human CASP3 gene. This protein plays a role in the promotion of apoptosis.
National Institutes of Health

Related topics

Related topics

12 relations
ApoptosisCASP3 geneCaspase ActivationCaspase Cascade Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Strategies to defeat ketamine-induced neonatal brain injury
2012
2012
Possible pathophysiology of heart failure in obesity: Cardiac apoptosis
2012
2012
Activity‐dependent survival of developing neocortical neurons depends on PI3K signalling
J. Neurochem. (2012) 120, 495–501. 
2010
2010
Effects of 17beta‐estradiol on cardiac apoptosis in ovariectomized rats
Cardiac apoptosis was found in ovariectomized rats without ischemia. Limited information regarding the protective effects of 17… 
2009
2009
Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human…
Highly Cited
2003
Highly Cited
2003
Inhibitory Cardiac Transcription Factor, SRF-N, Is Generated by Caspase 3 Cleavage in Human Heart Failure and Attenuated by Ventricular Unloading
Background—Knowledge about molecular mechanisms leading to heart failure is still limited, but reduced gene activities and modest… 
Highly Cited
2003
Highly Cited
2003
All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathway.
Current treatments for childhood brain tumor medulloblastoma (MB), radiation and chemotherapy, lead to undesirable side effects… 
Highly Cited
2001
Highly Cited
2001
Blocking caspase-activated apoptosis improves contractility in failing myocardium.
Cardiac myocyte apoptosis has been demonstrated in end-stage failing human hearts. The therapeutic utility of blocking apoptosis… 
Highly Cited
2000
Highly Cited
2000
Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members.
Hematopoietic progenitor cells (HPC) from mice nullizygous at the Fanconi anemia (FA) group C locus and children with Fanconi… 
1999
1999
Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis.
The colonic epithelial cells near the top of the crypt and in the lumen have been shown to undergo apoptosis. Since butyric acid… 
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