Activated Caspase-3

Known as: Activated Caspase 3 
Activated caspase-3 (249 aa, ~29 kDa) is encoded by the human CASP3 gene. This protein plays a role in the promotion of apoptosis.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
In cancer treatment, apoptosis is a well-recognized cell death mechanism through which cytotoxic agents kill tumor cells. Here we… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
The mammalian innate immune system is activated by foreign nucleic acids. Detection of double-stranded DNA (dsDNA) in the… (More)
Is this relevant?
Review
2008
Review
2008
Apoptosis (programmed cell death) is an active process that plays a critical role in multiple biologic processes from embryologic… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
We previously reported that cells harboring the hepatitis C virus (HCV) RNA replicon as well as those expressing HCV NS3/4A… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS Steroid-refractory Crohn's disease responds to therapy with the chimeric anti-tumor necrosis factor (TNF)-alpha… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
MCF-7 human breast cancer cells do not express caspase 3, thought by some to be a critical component of the apoptosis cascade… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Forced overexpression of wild-type Alzheimer amyloid precursor protein (APP) causes postmitotic neurons to degenerate. Caspase-3… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Activation of caspase-3 requires proteolytic processing of the inactive zymogen into p18 and p12 subunits. We generated a rabbit… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The death receptor Fas transduces apoptotic death signaling mediated by caspases. In the present study, human hepatoma HepG2… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?