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Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.
TLDR
Neutrophils are one of the professional phagocytes in humans that ingest bacteria into intracellular spaces and are involved in phagocytosis. Expand
Thiol chemistry and specificity in redox signaling.
TLDR
This review focuses on mechanisms for sensing and transmitting redox signals, from the perspective of their chemical reactivity with specific oxidants, and discusses substrate preferences for different oxidants and how the kinetics of these reactions determines how each oxidant will react in a cell. Expand
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling.
TLDR
Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies, and the extent of this role and the mechanisms involved are currently unclear. Expand
Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte.
TLDR
It is demonstrated that in the erythrocyte Prx2 is extremely efficient at scavenging H(2)O( 2) noncatalytically, although it does not act as a classical antioxidant enzyme, and this may account for its nonredundant role in ery Throcyte defense against oxidative stress. Expand
Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome
TLDR
A kinetic model is used to examine the fate of superoxide and its interactions with myeloperoxidase and finds that HOCl production is efficient if there is adequate chloride supply and further knowledge on chloride concentrations and transport mechanisms is needed to assess whether this is the case. Expand
The High Reactivity of Peroxiredoxin 2 with H2O2 Is Not Reflected in Its Reaction with Other Oxidants and Thiol Reagents*
TLDR
Results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents. Expand
Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus
TLDR
This work investigated the role of oxidants in NET formation by human neutrophils induced with PMA, several bacterial genera, and the calcium ionophore ionomycin and observed that requirements for oxidant generation depend on the stimulus. Expand
Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species.
TLDR
It is concluded that caspases are an important component of constitutive and Fas/APO-1-triggered neutrophil apoptosis, however, these redox sensitive enzymes are suppressed in activated neutrophils, and an alternate oxidant-dependent pathway is used to mediate PS exposure and neutrophIL clearance under these conditions. Expand
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation.
TLDR
It is concluded that auranofin induces apoptosis in cells through a Bax/Bak-dependent mechanism associated with selective disruption of mitochondrial redox homeostasis in conjunction with oxidation of Prx3. Expand
Reactive Oxygen Species and Neutrophil Function.
TLDR
The identity and chemical properties of the specific oxidants produced by neutrophils in different situations are discussed, and what is known about oxidative mechanisms of microbial killing, inflammatory tissue damage, and signaling is discussed. Expand
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