DIABLO protein, human

Known as: Smac protein, human, second mitochondria-derived activator of caspase, human, smac mitochondrial protein, human 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2017
024620042017

Papers overview

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Review
2018
Review
2018
BACKGROUND Smac mimetics (also known as IAP antagonist) are a new class of targeted drugs having a goal to suppress the IAPs… (More)
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2016
2016
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor… (More)
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2011
2011
The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The… (More)
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2009
2009
XIAP is an apoptotic regulator protein that binds to the effector caspases -3 and -7 through its BIR2 domain, and to initiator… (More)
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2009
2009
Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. Several compounds… (More)
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2008
2008
The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in several malignant cells where it prevents apoptosis by… (More)
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Highly Cited
2005
Highly Cited
2005
A key step in the initiation of apoptosis is the release from the mitochondrial intermembrane space of cytochrome c and other pro… (More)
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2004
2004
Smac/DIABLO, a pro-apoptotic protein released from mitochondrial intermembrane space during apoptosis, promotes caspase… (More)
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2004
2004
A successful structure-based design and synthesis of a class of highly potent conformationally constrained Smac mimetics is… (More)
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