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Most deaths from breast cancer result from tumour recurrence, which is typically an incurable disease. Down-regulation of the pro… Expand BACKGROUND
Smac mimetics (also known as IAP antagonist) are a new class of targeted drugs having a goal to suppress the IAPs… Expand Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of… Expand Background Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor… Expand The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The… Expand XIAP is an apoptotic regulator protein that binds to the effector caspases -3 and -7 through its BIR2 domain, and to initiator… Expand The activating E2f transcription factors (E2f1, E2f2 and E2f3) induce transcription and are widely viewed as essential positive… Expand The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in several malignant cells where it prevents apoptosis by… Expand Smac/DIABLO, a pro‐apoptotic protein released from mitochondrial intermembrane space during apoptosis, promotes caspase… Expand