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DIABLO protein, human

Known as: Smac protein, human, second mitochondria-derived activator of caspase, human, smac mitochondrial protein, human 
National Institutes of Health

Papers overview

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2019
2019
Most deaths from breast cancer result from tumour recurrence, which is typically an incurable disease. Down-regulation of the pro… Expand
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Review
2018
Review
2018
BACKGROUND Smac mimetics (also known as IAP antagonist) are a new class of targeted drugs having a goal to suppress the IAPs… Expand
2016
2016
Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of… Expand
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Highly Cited
2013
Highly Cited
2013
Background Necroptosis/programmed necrosis is initiated by a macro-molecular protein complex termed the necrosome. Receptor… Expand
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Highly Cited
2011
Highly Cited
2011
The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The… Expand
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2009
2009
XIAP is an apoptotic regulator protein that binds to the effector caspases -3 and -7 through its BIR2 domain, and to initiator… Expand
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Highly Cited
2009
Highly Cited
2009
The activating E2f transcription factors (E2f1, E2f2 and E2f3) induce transcription and are widely viewed as essential positive… Expand
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2008
2008
The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in several malignant cells where it prevents apoptosis by… Expand
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2004
2004
Smac/DIABLO, a pro‐apoptotic protein released from mitochondrial intermembrane space during apoptosis, promotes caspase… Expand