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DAG/PE-Binding Domain

Known as: C1 Domain, Diacylglycerol Binding Domain, Phorbol Ester Binding Domain 
The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the… 
National Institutes of Health

Related topics

Related topics

16 relations
BRAF protein, humanChimerin 1Diacylglycerol Kinase AlphaDiacylglycerol Kinase Eta, human

Papers overview

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Review
2011
Review
2011
Current status and future prospects of C1 domain ligands as drug candidates.
The second messenger diacylglycerol (DAG) plays a central role in the signal transduction of G-protein coupled receptors and… 
2009
2009
A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation
Genetic and biochemical data support Kinase Suppressor of Ras 1 (KSR1) as a positive regulator of the Ras-Raf-MAPK pathway… 
Highly Cited
2007
Highly Cited
2007
Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.
RasGRPs (guanine-nucleotide-releasing proteins) are exchange factors for membrane-bound GTPases. All RasGRP family members… 
Highly Cited
2006
Highly Cited
2006
Effects on Ligand Interaction and Membrane Translocation of the Positively Charged Arginine Residues Situated along the C1 Domain Binding Cleft in the Atypical Protein Kinase C Isoforms*
The C1 domain zinc finger structure is highly conserved among the protein kinase C (PKC) superfamily members. As the interaction… 
Review
2005
Review
2005
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.
Tumor promoters such as phorbol esters bind strongly to protein kinase C (PKC) isozymes to induce their activation. Since each… 
Highly Cited
2003
Highly Cited
2003
Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C.
The hallmark for protein kinase C activation is its "translocation" to membranes following generation of lipid second messengers… 
Review
2002
Review
2002
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.
2002
2002
Regulation of tumor invasion and metastasis in protein kinase C epsilon‐transformed NIH3T3 fibroblasts
Protein kinase C epsilon is an oncogenic, actin nucleating protein that coordinately regulates changes in cell growth and shape… 
1991
1991
NPC 15437 interacts with the C1 domain of protein kinase C An analysis using mutant PKC constructs
1985
1985
Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences.
The high degree of polymorphism found among the class I genes of the murine major histocompatibility complex (H-2) has led to the… 
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