BRAF protein, human

Known as: v-raf murine sarcoma viral oncogene homolog B1, human, B-RAF Serine/Threonine Protein Kinase, RAFB1 Protein 
Serine/threonine-protein kinase B-raf (766 aa, ~84 kDa) is encoded by the human BRAF gene. This protein plays a role in protein phosphorylation… (More)

Topic mentions per year

Topic mentions per year

1981-2018
0500100019812018

Papers overview

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Review
2016
Review
2016
Patients with advanced melanoma have traditionally had very poor prognosis. However, since 2011 better understanding of the… (More)
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Review
2015
Review
2015
INTRODUCTION BRAF inhibition alone has achieved unprecedented efficacy results in patients affected by BRAF-mutated advanced… (More)
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Review
2015
Review
2015
The liver is the most common site of colorectal cancer metastasis. Fortunately, improvements have been made in the care of… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Activating mutations in serine-threonine protein kinase B-RAF (BRAF) are found in 50% of patients with advanced… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The identification of somatic mutations in the gene encoding the serine-threonine protein kinase B-RAF (BRAF) in the… (More)
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Highly Cited
2010
Highly Cited
2010
Tumours with mutant BRAF are dependent on the RAF-MEK-ERK signalling pathway for their growth. We found that ATP-competitive RAF… (More)
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Highly Cited
2010
Highly Cited
2010
We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Cetuximab or panitumumab are effective in 10% to 20% unselected metastatic colorectal cancer (CRC) patients. KRAS… (More)
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Highly Cited
2006
Highly Cited
2006
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase… (More)
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